{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:36:57Z","timestamp":1783539417944,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012269","name":"Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province","doi-asserted-by":"publisher","award":["2023233"],"award-info":[{"award-number":["2023233"]}],"id":[{"id":"10.13039\/501100012269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019054","name":"Changsha Science and Technology Project","doi-asserted-by":"publisher","award":["kq2303001"],"award-info":[{"award-number":["kq2303001"]}],"id":[{"id":"10.13039\/501100019054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This retrospective multicenter study is aimed at evaluating the diagnostic accuracy and influence factors of serum des\u2010gamma\u2010carboxy prothrombin (DCP) as a diagnostic biomarker of hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data were collected from 4555 subjects with DCP tests, composed of primary liver cancer (PLC), metastatic liver cancer (MLC), chronic hepatitis (CH), liver cirrhosis (LC), benign liver diseases (BLD), biliary tract diseases (BTD), non\u2010liver cancers (NLC), and non\u2010liver benign diseases (NLBD). The clinical data collected included medical history, treatment records, various serum tests, and imaging examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum DCP was measured with Abbott agents in each center. In HCC, serum DCP concentration was at 9086.00\u2009\u00b1\u2009366.10 mAU\/mL, higher than that in other diseases (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). At 40.00 mAU\/mL recommended by instruction, positive rates of serum DCP were at 85.11% in HCC, 30.12% in intrahepatic cholangiocellular carcinoma (ICC), 31.65% in MLC, 13.95% in BLD, 18.14% in CH, 27.87% in LC, 15.75% in BTD, 35.29% in NLC, and 20.00% in NLBD. In this study, the diagnostic specificity of serum DCP in HCC was affected by liver function. In HCC, serum AFP concentrations also increased compared to non\u2010HCC diseases (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but specificity varied with agents from different providers. Serum DCP decreased after the surgical removal of HCC, but remained elusive in systemic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum DCP may serve as an optimal biomarker for the diagnosis of HCC, but its accuracy appears influenced by liver function; attention needs to be paid to the liver function of patients for false positivity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70025","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:00:19Z","timestamp":1744711219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Large\u2010Scale Retrospective Study of Serum Des\u2010Gamma\u2010Carboxy Prothrombin as a Diagnostic Marker of <scp>HCC<\/scp>: Effect of Liver Function on Specificity"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6565-5715","authenticated-orcid":false,"given":"Hongying","family":"Bu","sequence":"first","affiliation":[{"name":"School of Public Health, Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Luo","sequence":"additional","affiliation":[{"name":"Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School University of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Tao","sequence":"additional","affiliation":[{"name":"Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer 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