{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:12Z","timestamp":1753869372183,"version":"3.41.2"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.MAZUMS.REC.1400.644"],"award-info":[{"award-number":["IR.MAZUMS.REC.1400.644"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The emergence of COVID\u201019 has led to a significant public health crisis, and an increase in fungal infections, including candidemia. <jats:italic>Candida<\/jats:italic> species are frequently found in intensive care units (ICUs), and it is a common cause of death in many patients. The isolates were identified using polymerase chain reaction\u2010restriction. In this study, We investigated the factors linked to <jats:italic>Candida<\/jats:italic> infections in COVID\u201019 burn patients in the ICU and assessed the antifungal susceptibility of the isolates in\u00a0vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Out of 335 burn patients admitted to the ICU, fifty\u2010six with concurrent COVID\u201019 were included in this study. A total of 133 yeast isolates were obtained from burn wounds, 29 from blood cultures, and 36 from urine cultures. The isolates were identified using polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of fifty\u2010six patients, twenty\u2010nine had infections and forty\u2010eight had colonization, with <jats:styled-content style=\"fixed-case\"><jats:italic>Candida parapsilosis<\/jats:italic><\/jats:styled-content> being the most common species. Twenty\u2010one patients died during their ICU stay, with mortality rates of 43.8% among colonized patients and 69.0% among infected patients. Fluconazole and itraconazole exhibited the highest minimum inhibitory concentrations, while luliconazole and amphotericin B were identified as the most effective antifungal agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that colonization may act as an important prognostic factor prior to the onset of candidemia. In addition, prolonged hospitalization, catheter use, and concurrent COVID\u201019 infection were identified as key risk factors for candidemia in this patient group. Notably, the rising drug resistance in non\u2010<jats:italic>albicans Candida<\/jats:italic> species is a major public health concern.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70031","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:27:33Z","timestamp":1744126053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of <scp>COVID<\/scp>\u201019\u2010Associated Candidemia Among Burn Patients"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8288-2555","authenticated-orcid":false,"given":"Maryam","family":"Salimi","sequence":"first","affiliation":[{"name":"Student Research Committee School of Medicine, Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Invasive Fungi Research Center Communicable Diseases Institute, Mazandaran University of Medical Sciences  Sari 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