{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:10:58Z","timestamp":1780546258348,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["CIFMS, 2019"],"award-info":[{"award-number":["CIFMS, 2019"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Augmented renal clearance (ARC) refers to a phenomenon in critically ill patients characterized by increased creatinine clearance. Neurological patients seem to be at higher risk compared with other groups. The epidemiology study of ARC reported in critically ill neurological patients varies substantially with the definitions used and the population evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to describe the prevalence of ARC and to explore risk factors in critically ill neurological patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational study was conducted in a university\u2010affiliated neurocritical care unit (NCCU). Study participants had a serum creatinine concentration (Scr)\u2009&lt;\u2009120\u2009\u03bcmol\/L. Kidney function was assessed by the 24\u2010h creatinine clearance (CL<jats:sub>cr<\/jats:sub>); ARC was defined as CLcr\u2009\u2265\u2009120\u2009mL\/min\/1.73m<jats:sup>2<\/jats:sup> in women and\u2009\u2265\u2009130\u2009mL\/min\/1.73m<jats:sup>2<\/jats:sup> in men. The prevalence and clinical characteristics of ARC were evaluated. Multivariate logistic regression analysis was used to assess variables associated with ARC occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 137 patients, 56.2% were male, and the mean age was 50.2 (17.4) years. ARC was present in 55.5% of the NCCU patients, ranging from 50% in intracranial infection to 75% in patients with spinal lesions. ARC patients have a mean CL<jats:sub>cr<\/jats:sub>159.3 (IQR:139.6\u2013185.2) ml\/min\/1.73m<jats:sup>2<\/jats:sup>. Age was the only factor independently associated with ARC (OR 0.996, 95% CI: 0.934\u20130.999, <jats:italic>p<\/jats:italic>\u2009=\u20090.043) in multivariable logistic analysis. Scr (Pearson correlation\u2009=\u2009\u22120.477) and cystatin C (Pearson correlation\u2009=\u2009\u22120.336) were found to have a negative correlation with ARC with statistically significant effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ARC is prevalent in critically neurological patients. Age is likely to significantly influence renal clearance in this population, especially as patients with low Scr and cystatin C levels should be given more attention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70047","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:05:08Z","timestamp":1747807508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Prevalence<\/scp> and Risk Factors for Augmented Renal Clearance in Neurocritical Ill Patients"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-5617","authenticated-orcid":false,"given":"Xiangru","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurosurgery &amp; Neurocritical Care, Huashan Hospital Fudan University  Shanghai China"},{"name":"Research Unit of New Technologies of Micro\u2010Endoscopy Combination in Skull Base Surgery (2018RU00) Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery &amp; 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Neurocritical Care, Huashan Hospital Fudan University  Shanghai China"},{"name":"Research Unit of New Technologies of Micro\u2010Endoscopy Combination in Skull Base Surgery (2018RU00) Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biwu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery &amp; Neurocritical Care, Huashan Hospital Fudan University  Shanghai China"},{"name":"Research Unit of New Technologies of Micro\u2010Endoscopy Combination in Skull Base Surgery (2018RU00) Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery &amp; Neurocritical Care, Huashan Hospital Fudan University  Shanghai China"},{"name":"Research Unit of New Technologies of Micro\u2010Endoscopy Combination in Skull Base Surgery (2018RU00) Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Shi","sequence":"additional","affiliation":[{"name":"Nursing Department, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Nursing Department, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Nursing Department, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihua","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery &amp; 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