{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:13Z","timestamp":1753869373414,"version":"3.41.2"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"ABSTRACT<\/jats:title>Aim<\/jats:title>This study aimed to determine the important features and cut\u2010off values after demonstrating the detectability of cirrhosis using routine laboratory test results of chronic hepatitis C (CHC) patients in machine learning (ML) algorithms.<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective multicenter (37 referral centers) study included the data obtained from the Hepatitis C Turkey registry of 1164 patients with biopsy\u2010proven CHC. Three different ML algorithms were used to classify the presence\/absence of cirrhosis with the determined features.<\/jats:p><\/jats:sec>Results<\/jats:title>The highest performance in the prediction of cirrhosis (Accuracy\u2009=\u20090.89, AUC\u2009=\u20090.87) was obtained from the Random Forest (RF) method. The five most important features that contributed to the classification were platelet, \u03b1lpha\u2010feto protein (AFP), age, gamma\u2010glutamyl transferase (GGT), and prothrombin time (PT). The cut\u2010off values of these features were obtained as platelet <\u2009182.000\/mm3<\/jats:sup>, AFP >\u20095.49\u2009ng\/mL, age\u2009>\u200952\u2009years, GGT >\u200939.9\u2009U\/L, and PT >\u200912.35\u2009s. Using cut\u2010off values, the risk coefficients were AOR\u2009=\u20094.82 for platelet, AOR\u2009=\u20093.49 for AFP, AOR\u2009=\u20094.32 for age, AOR\u2009=\u20093.04 for GGT, and AOR\u2009=\u20092.20 for PT.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings indicated that the RF\u2010based ML algorithm could classify cirrhosis with high accuracy. Thus, crucial features and cut\u2010off values for physicians in the detection of cirrhosis were determined. In addition, although AFP is not included in non\u2010invasive indexes, it had a remarkable contribution in predicting cirrhosis.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>Clinicaltrials.gov identifier: NCT03145844<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70054","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:20:22Z","timestamp":1747646422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assisting the Diagnosis of Cirrhosis in Chronic Hepatitis C Patients Based on Machine Learning Algorithms: A Novel Non\u2010Invasive Approach"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-1326","authenticated-orcid":false,"given":"Emre","family":"Dirican","sequence":"first","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine, Hatay Mustafa Kemal University Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayibe","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Bolu Abant Izzet Baysal University Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Onlen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Bolu Abant Izzet Baysal University Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Sarigul","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulku","family":"User","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagehan Didem","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behice","family":"Kurtaran","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Cukurova University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebubekir","family":"Senates","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Medicana International Istanbul Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Sisli Hamidiye Etfal Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-6639","authenticated-orcid":false,"given":"Esra","family":"Zerdali","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Karsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Harran University Sanl\u0131urfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Batirel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Dr. Lutfi Kirdar Kartal Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ridvan","family":"Karaali","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Rahmet","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tansu","family":"Yamazhan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Ege University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukran","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Dokuz Eyl\u00fcl University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurettin","family":"Erben","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin Koc","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Duzce University Duzce Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftihar","family":"Koksal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Acibadem University, Atakent Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nefise","family":"Oztoprak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulsen","family":"Yoruk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suheyla","family":"Komur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Cukurova University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel Yildiz","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa Corum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkay","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Ondokuz Mayis University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Gunal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Samsun University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur Esen","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Recep Tayyip Erdo\u011fan University Rize Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Inan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sener","family":"Barut","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Dokuz Eyl\u00fcl University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Namiduru","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Gaziantep University Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Bozyaka Training and Research Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamuran","family":"Turker","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Ba\u011fc\u0131lar Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Izmir Katip Celebi Training and Research Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Hizel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurcan","family":"Baykam","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Hitit University Corum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazilet","family":"Duygu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Gaziosmanpa\u015fa University Tokat Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hurrem","family":"Bodur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guray","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine, Abant Izzet Baysal University Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanefi Cem","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Sagmak","family":"Tartar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, F\u0131rat University Elaz\u0131g Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guven","family":"Celebi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Zonguldak Bulent Ecevit University Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Sunnetcioglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Sakarya University Sakarya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguz","family":"Karabay","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine, Sakarya University Sakarya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayat","family":"Kumbasar Karaosmanoglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Health Sciences University, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Sirmatel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Izmir T\u0131naztepe University Faculty of Medicine \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer Fehmi","family":"Tabak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Cerrahpasa Faculty of Medicine, Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Organization WH \u201cGlobal Progress Report on HIV Viral Hepatitis and Sexually Transmitted Infections\u201d(2021) https:\/\/www.who.int\/publications\/i\/item\/9789240027077."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(19)32320\u20107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.07.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.013"},{"key":"e_1_2_8_6_1","unstructured":"I.HanifandM. M.Khan \u201cLiver Cirrhosis Prediction Using Machine Learning Approaches\u201d(2022) IEEE:28\u201034."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0081"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100067"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6679512"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asoc.2015.02.034"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpe.7628"},{"issue":"31","key":"e_1_2_8_13_1","first-page":"114","article-title":"A Proposed Framework for Predictive Analytics for Cirrhosis of the Liver Using Machine Learning","volume":"31","author":"Bedeir A.","year":"2023","journal-title":"Journal of the Egyptian Society for Information Systems and Computer Technology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/127962"},{"issue":"1","key":"e_1_2_8_15_1","first-page":"95","article-title":"Deep Learning Based Cirrhosis Detection","volume":"6","author":"Utku A.","year":"2023","journal-title":"Operational Research in Engineering Sciences: Theory and Applications"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07642-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4236\/jis.2016.73009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20172555"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.6000\/1927-5129.2017.13.76"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isprsjprs.2011.11.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/LGRS.2008.915597"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40708-017-0065-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-019-0681-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.4710300805"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4085"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06295361"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.08.011"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00097-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618791053"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.065"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8062410"},{"key":"e_1_2_8_35_1","first-page":"5382","article-title":"Assisting the Non\u2010Invasive Diagnosis of Liver Fibrosis Stages Using Machine Learning Methods","volume":"2020","author":"Emu M.","year":"2020","journal-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.32604\/cmc.2021.015436"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","unstructured":"A.AkellaandS.Akella \u201cApplying Machine Learning to Evaluate for Fibrosis in Chronic Hepatitis C\u201d(2020) medRxiv.","DOI":"10.1101\/2020.11.02.20224840"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2021.04.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13729"},{"key":"e_1_2_8_40_1","first-page":"89","article-title":"Hepatitis C Virus (HCV) Prediction by Machine Learning Techniques","volume":"4","author":"Nandipati S. C.","year":"2020","journal-title":"Applications of Modelling and Simulation"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eij.2018.03.002"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100925"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199760"},{"issue":"6","key":"e_1_2_8_44_1","first-page":"1","article-title":"Machine Learning in Healthcare Data Analysis: A Survey","volume":"8","author":"Dhillon A.","year":"2019","journal-title":"Journal of Biology and Today's World"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010020\u201001908\u20101"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10181"},{"issue":"3","key":"e_1_2_8_48_1","first-page":"4787","article-title":"Evaluation of the Role of Alpha\u2010Fetoprotein (AFP) Levels in Chronic Viral Hepatitis C Patients, Wit\u2010Hout Hepatocellular Carcinoma (HCC)","volume":"3","author":"Dabbous H.","year":"2015","journal-title":"Journal of Medical Science and Clinical Research"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.03.019"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00703.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9024300"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322202"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010020\u201001365\u20101"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.860"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2005.03828.x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.186"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v12.i3.40"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2019.07.021"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.01.005"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T12:05:48Z","timestamp":1750421148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jcla.70054"],"URL":"https:\/\/doi.org\/10.1002\/jcla.70054","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"type":"print","value":"0887-8013"},{"type":"electronic","value":"1098-2825"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2023-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70054"}}