{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:20:00Z","timestamp":1790565600460,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Activation of the IL\u201023\/IL\u201017 cytokine axis could trigger peri\u2010implant bone loss. The aim of this review was to analyze whether in people with peri\u2010implantitis (PI) and peri\u2010implant mucositis (PM) the concentrations of the interleukin\u201023 and interleukin\u201017 in peri\u2010implant crevicular fluid (PICF) are elevated compared to people with healthy dental implants (HDI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>The protocol of this study was registered in OSF (ID: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.17605\/OSF.IO\/U8NBQ\">10.17605\/OSF.IO\/U8NBQ<\/jats:ext-link>) and followed PRISMA guidelines. PECO criteria were used to formulate the research question. A search strategy was performed using PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar until November 15, 2024. A rigorous evaluation was performed, and the JBI tool was used to assess the quality of the cross\u2010sectional and case\u2013control studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen observational studies were included in this study, with a total of 587 participants carrying 601 dental implants. The control group was represented by 252 healthy implants, while the exposure group was represented by 113 implants with PM and 236 implants with peri\u2010implantitis. The age range of the subjects varied from 40.8 to 68.6\u2009years, with a mean age\u2009\u00b1\u2009standard deviation of 53.9\u2009\u00b1\u20099.9\u2009years. The concentration of the IL\u201023\/IL\u201017 cytokine axis and isoforms (IL\u201017E and IL\u201017F) was higher in subjects with peri\u2010implant disease compared to the healthy population. Most of the studies (92.8%) showed moderate quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concentrations of cytokines IL\u201023, IL\u201017, and IL\u201017E in PICF were higher in PI\u2010affected dental implants, followed by PM\u2010affected dental implants compared to HDI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70071","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T01:25:08Z","timestamp":1750641908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Interleukin\u201023 and Interleukin\u201017 in Peri\u2010Implant Crevicular Fluid of Subjects With Peri\u2010Implant Disease: A Systematic Review"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7969","authenticated-orcid":false,"given":"Mario Alberto","family":"Alarc\u00f3n\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Molecular Biology in Medicine Program, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"},{"name":"Department of Integral Dental Clinics, Institute of Research in Dentistry, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9321-0095","authenticated-orcid":false,"given":"Julieta Sarai","family":"Becerra\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Clinics, Los Altos University Center University of Guadalajara (CUALTOS\u2010UdeG)  Tepatitl\u00e1n de Morelos Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-0334","authenticated-orcid":false,"given":"Ruth","family":"Rodr\u00edguez\u2010Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Integral Dental Clinics, Institute of Research in Dentistry, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"},{"name":"Department of Health and Illness as an Individual and Collective Process, University Center of Tlajomulco University of Guadalajara (CUTLAJO\u2010UdeG)  Tlajomulco de Zu\u00f1iga Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-1387","authenticated-orcid":false,"given":"Sarah Monserrat","family":"Lomel\u00ed\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center University of Guadalajara (CUCI\u00c9NEGA\u2010UdeG)  Ocotl\u00e1n Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-8732","authenticated-orcid":false,"given":"Lilibeth\u2010Stephania","family":"Escoto\u2010Vasquez","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, Postgraduate Division, Dental School National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University  Chennai India"},{"name":"Department of Prosthodontics, Faculty of Stomatology Yerevan State Medical University after Mkhitar Heratsi  Yerevan Armenia"},{"name":"Department of Prosthodontics, School of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415\u2010024\u20107402\u2010z"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","unstructured":"M. H. A.Saleh D. R.Dias andP.Kumar \u201cThe Economic and Societal Impact of Periodontal and Peri\u2010Implant Diseases \u201dPeriodontology 2000(2024) https:\/\/doi.org\/10.1111\/prd.12568.","DOI":"10.1111\/prd.12568"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/187215"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12112214"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13608"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12061137"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj12080251"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12683"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2024.10.007"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114147"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010024\u201002039\u20104"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114085"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.10353"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010021\u201004061\u2010w"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105026"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2023.03.012"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.11138\/oi.v17i1.111"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043202"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143394"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004077\u20100"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1535"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxae033"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41405\u2010024\u201000193\u20109"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13896"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179802"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195817"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.932243"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13850"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_27_19"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010471"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12886"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12586"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.08.021"},{"issue":"1","key":"e_1_2_13_35_1","first-page":"75","article-title":"Comparison of the Levels of Tumor Necrosis Factor\u2010\u03b1 and Interleukin\u201017 in Gingival Crevicular Fluid of Patients With Peri\u2010Implantitis and a Control Group With Healthy Implants","volume":"12","author":"Darabi E.","year":"2013","journal-title":"Iranian Journal of Allergy, Asthma, and Immunology"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.01.006"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-08"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2023.46.8.41130"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0308478"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010024\u201002409\u20109"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12018\u2010023\u201009286\u20109"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14144"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11071845"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.9659"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13982"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14935"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345241291533"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.13270"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1466417"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7279509"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.70147"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.9271"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12456"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116500"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.139498"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2023.11.005"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12354"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9040214"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T08:01:02Z","timestamp":1754553662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,22]]},"references-count":58,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jcla.70071"],"URL":"https:\/\/doi.org\/10.1002\/jcla.70071","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,22]]},"assertion":[{"value":"2025-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70071"}}