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This study aimed to investigate the prognostic value of novel inflammatory biomarkers for predicting in\u2010hospital mortality in patients with community\u2010acquired pneumonia (CAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cross\u2010sectional study included 207 hospitalized patients diagnosed with clinically and radiologically confirmed pneumonia. Laboratory data collected upon admission included complete blood count parameters, C\u2010reactive protein (CRP), creatinine, and albumin levels. Systemic inflammatory biomarkers such as the neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), CRP\u2010to\u2010albumin ratio (CAR), CRP\u2010to\u2010lymphocyte ratio (CLR), systemic immune\u2010inflammation index (SII), systemic inflammatory response index (SIRI), prognostic nutritional index (PNI), and C\u2010reactive protein\u2010albumin\u2010lymphocyte (CALLY) index were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort was predominantly male (69%, <jats:italic>n<\/jats:italic>\u2009=\u2009142) with a mean age of 62.1\u2009\u00b1\u200916.3\u2009years. The median hospital stay was 8\u2009days, with an 11% mortality rate. Malignancy was more frequent in the nonsurvivor group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Nonsurvivors had significantly lower hemoglobin (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and albumin (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) levels, while CRP (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and creatinine (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) were elevated. NLR (<jats:italic>p<\/jats:italic>\u2009=\u20090.009), CAR (<jats:italic>p<\/jats:italic>\u2009=\u20090.011), CLR (<jats:italic>p<\/jats:italic>\u2009=\u20090.006), SII (<jats:italic>p<\/jats:italic>\u2009=\u20090.013), and SIRI (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) were higher in nonsurvivors, while PNI (<jats:italic>p<\/jats:italic>\u2009=\u20090.010) and CALLY (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) were lower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Novel inflammatory biomarkers, particularly the CALLY index, are valuable for mortality prediction in CAP, aiding in risk stratification and early management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70081","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:42:57Z","timestamp":1755092577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of Mortality Risk in Patients With Community\u2010Acquired Pneumonia: Role of Novel Inflammatory Biomarkers"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-3140","authenticated-orcid":false,"given":"Burcu","family":"Baran","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases Erciyes University Medical School  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5974-9129","authenticated-orcid":false,"given":"Nur Aleyna","family":"Yetkin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Erciyes University Medical School  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-4073","authenticated-orcid":false,"given":"Bilal","family":"Rabaho\u011flu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Erciyes University Medical School  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-4896","authenticated-orcid":false,"given":"Nuri","family":"Tutar","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Erciyes University Medical School  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-2213","authenticated-orcid":false,"given":"\u0130nci","family":"G\u00fclmez","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Erciyes University Medical School  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Pneumonia [Internet]","author":"World Health Organization","year":"2023"},{"key":"e_1_2_11_3_1","volume-title":"Centers for Disease Control and Prevention (CDC). 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