{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:42:03Z","timestamp":1758040923825,"version":"3.44.0"},"reference-count":22,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Homologous recombination repair (HRR) is the preferred pathway for repairing double\u2010strand DNA breaks, using proteins like BRCA1 and BRCA2, among others, while the PARP\u2010mediated repair pathway is primarily used for single\u2010strand breaks. When a tumour becomes HRR\u2010deficient (HRD), then those tumour cells become reliant on PARP\u2010mediated repair. Poly ADP\u2010ribose polymerase inhibitors, olaparib and niraparib, have been approved in Australia for advanced (FIGO III\u2010IV), high\u2010grade serous or other high\u2010grade ovarian, fallopian tube or primary peritoneal carcinoma with homologous recombination deficiency (HRD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HRDsig (Roche Inc) is a new HRD biomarker that is part of the AVENIO Tumor Tissue CGP Kit V2. We have studied the performance of HRDsig against two NATA (National Association of Testing Authorities, Australia) accredited HRD assays in the cases of high\u2010grade ovarian carcinomas. We have evaluated the performance of HRDsig using a total 40 HRD results against the two accredited HRD assays, as well as against commercial controls and inter\u2010laboratory comparison samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HRDsig has demonstrated a high concordance rate for HRD by comparing it with two different locally accredited HRD assays in cases of ovarian cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide real\u2010world evidence of the performance of a new HRD assay (HRDsig) in ovarian carcinomas.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70085","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:59:44Z","timestamp":1752911984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance Evaluation of a New HRD Assay (HRDsig) in Ovarian Carcinomas in Australia"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-8745","authenticated-orcid":false,"given":"Pranav","family":"Dorwal","sequence":"first","affiliation":[{"name":"Genetics and Molecular Pathology Monash Health  Clayton Victoria Australia"},{"name":"Anatomical Pathology Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences, Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Song","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Pathology Monash Health  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscillia","family":"Siswara","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Pathology Monash Health  Clayton Victoria 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