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The PCR\u2010RFLP technique was used to determine the genotypes of VDR <jats:italic>FokI<\/jats:italic> T&gt;C (rs2228570). The oxidative stress parameters were measured using chemical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In individuals with diabetes, there were significantly higher levels of body mass index (BMI) and oxidative stress than in controls. The presence of the FokI CC genotype and the C allele were associated with 2.46 times and 1.6\u2010fold increased risk of T2DM, respectively, and enhanced diabetic neuropathy risk by 3.41\u2010 and 3.68\u2010fold, respectively, and elevated diabetic retinopathy risk by 2.45 and 1.59 times, respectively. The presence of FokI TC\u2009+\u2009CC compared to the TT genotype resulted in higher triglycerides, total oxidative status, and BMI levels in individuals with diabetes. We found significantly higher BMI, oxidative stress index, and significantly lower levels of total antioxidant capacity in females than in males among individuals with diabetes and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates that the <jats:italic>FokI<\/jats:italic> CC genotype and the <jats:italic>FokI<\/jats:italic> C allele are associated with an increased risk of T2DM and its complications. We observed the influence of VDR <jats:italic>FokI<\/jats:italic> variants on dyslipidemia, oxidative stress, and BMI. It seems the risk factors of developing T2DM, obesity, and oxidative stress among women are more prevalent than in men.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70090","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:24:27Z","timestamp":1759148667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of VDR <i>FokI<\/i> T&gt;C (rs2228570) Gene Variants With T2DM, and Its Complications: Influence on BMI, Oxidative Stress, and Dyslipidemia"],"prefix":"10.1002","volume":"39","author":[{"given":"Armin","family":"Sharifi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Medical School Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"Student Research Committee, Medical School Kermanshah University of Medical Sciences  Kermanshah 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