{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:04:44Z","timestamp":1792623884557,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Antifungal resistance in\n Candida<\/jats:italic>\n species in HIV\/AIDS patients due to the scarcity of antifungal agents is important particularly in Iran with an estimate of 46,000 individuals living with HIV. This systematic review and meta\u2010analysis aimed to determine the resistance rate of\n Candida<\/jats:italic>\n spp. isolates from HIV\/AIDS positive individuals in Iran from 1999 to 2024.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n PubMed, Scopus, Web of Science, MagIran, Scientific Information Database, and Google Scholar were searched and the title\u2010and\u2010abstract screening was performed independently by two review authors. The risk of bias assessment and the data extraction were performed independently by two review authors. Meta\u2010analysis was performed using a random\u2010effects model with Freeman\u2010Tukey double arcsine transformation. This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses 2020.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From the retrieved 4925 references, 18 references belonging to 15 studies with 1318\n Candida<\/jats:italic>\n spp. isolates were included. The highest pooled resistance rate of\n Candida<\/jats:italic>\n spp. was observed against clotrimazole (21%, 95% CI: 14\u201330,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200967.29%) while the lowest pooled resistance rates of\n Candida<\/jats:italic>\n spp. were observed against voriconazole, caspofungin, amphotericin B, and nystatin with the pooled estimates of 0%. At the species level, the highest pooled resistance rates were observed for\n \n Candida krusei<\/jats:italic>\n <\/jats:styled-content>\n against fluconazole (72%, 95% CI: 0%\u2013100%) and itraconazole (38%, 95% CI: 17%\u201362%), and for\n Candida glabrata<\/jats:italic>\n against clotrimazole (38%, 95% CI: 27%\u201350%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The use of amphotericin B, caspofungin, and nystatin for the treatment of\n Candida<\/jats:italic>\n spp. in HIV\u2010AIDS patients in Iran is recommended based on clinical indication.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n PROSPERO ID: CRD42024540580<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.70101","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:38:34Z","timestamp":1761305914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antifungal Resistance of\n Candida<\/i>\n spp. Isolates From\n HIV<\/scp>\n \/\n AIDS<\/scp>\n Patients in Iran 1999\u20132024: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-533X","authenticated-orcid":false,"given":"Aliasghar","family":"Fakhri\u2010Demeshghieh","sequence":"first","affiliation":[{"name":"DVM, Specialty Board\u2010Certified in Epidemiology, Department of Food Hygiene and Quality Control, Epidemiology & Zoonoses Division of Faculty of Veterinary Medicine, University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Yousefipour","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine, University of Tabriz Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Bolouki","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine, 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Veterinary Medicine, University of Tabriz Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-4378","authenticated-orcid":false,"given":"Farzad","family":"Katiraee","sequence":"additional","affiliation":[{"name":"Section of Mycology, Department of Pathobiology, Faculty of Veterinary Medecine, University of Tabriz Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Bokaie","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene and Quality Control Epidemiology & Zoonoses Division of Faculty of Veterinary Medicine, University of Tehran Tehran 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