{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:53:28Z","timestamp":1788584008684,"version":"build-2803163510"},"reference-count":97,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the innovative application of nanomaterial\u2010based micro\u2010devices aimed at enhancing the diagnosis and management of acyclovir (ACV) for herpes virus infections, specifically those caused by HSV\u20101, HSV\u20102, CMV, and VZV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Herpes viruses are associated with various clinical diseases, highlighting the urgent need for effective antiviral therapies. Acyclovir remains a primary treatment option; however, its potential for kidney toxicity and allergic reactions necessitates careful dosage monitoring, particularly in immunocompromised patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Recent advancements in drug monitoring systems have been developed to optimize dosing regimens and reduce the risk of misuse. This study focuses on the integration of biological and electrochemical nanosensors utilizing nanomaterials, which have shown significant improvements in detection capabilities and diagnostic sensitivity for ACV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We delineate the novel features and applications of these micro\u2010devices, emphasizing their unique configurations and unprecedented limits of detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This research illustrates how these advanced technologies can enhance existing methodologies in herpes virus management, ultimately leading to improved treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70104","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:05:52Z","timestamp":1759223152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanomaterial\u2010Enhanced Electrochemical Sensors for Clinical Monitoring of Acyclovir: Integration Into Molecular Diagnostics"],"prefix":"10.1002","volume":"39","author":[{"given":"Mohammad","family":"Darvishi","sequence":"first","affiliation":[{"name":"Infectious Disease, School of Aerospace and Subaquatic Medicine, Infectious Diseases &amp; Tropical Medicine Research Center(IDTMC), AJA University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kheradmand","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Health Management and Safety Promotion  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nava Moghadasian","family":"Niaki","sequence":"additional","affiliation":[{"name":"Women's Reproductive Health Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Tabean","sequence":"additional","affiliation":[{"name":"Women's Reproductive Health Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mobed","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Health Management and Safety Promotion  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14112386"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08564-w"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2023.0259"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17010133"},{"issue":"2","key":"e_1_2_16_6_1","first-page":"480","article-title":"Oral Microbiota and Inflammatory Bowel Diseases: Detection of Emerging Fungal Pathogens and Herpesvirus","volume":"13","author":"Oliveira M. 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