{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:05:57Z","timestamp":1777503957677,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZZYSM202311006"],"award-info":[{"award-number":["SZZYSM202311006"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The purpose of this research is to investigate the particular connection between the triglyceride to high\u2010density lipoprotein cholesterol (\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C) ratio and non\u2010alcoholic fatty liver disease (\n NAFLD<\/jats:styled-content>\n ) to offer a more precise foundation for evaluating\n NAFLD<\/jats:styled-content>\n risk.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study involves a secondary analysis of a retrospective cohort study conducted from 2004 to 2015 in a Japanese population, which included 14,106 participants. The\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C ratio was determined by the levels of triglycerides (\n TG<\/jats:styled-content>\n ) and high\u2010density lipoprotein cholesterol (\n HDL<\/jats:styled-content>\n \u2010C). Participants were grouped according to the quartiles of\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C. We analyzed the relationship between\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C and\n NAFLD<\/jats:styled-content>\n using Cox proportional hazards regression, smooth curve fitting, and sensitivity analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The average age of the study participants was 43.51\u2009\u00b1\u20098.89\u2009years, with 7275 (51.57%) being male. After considering potential confounding factors, the study found a positive correlation between\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C and\n NAFLD<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n : 1.37, 95%\n CI<\/jats:styled-content>\n : 1.31\u20131.43,\n p<\/jats:italic>\n \u2009<\u20090.001). Moreover, a nonlinear relationship between\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C and\n NAFLD<\/jats:styled-content>\n was found, with a turning point at 1.42. The odds ratio (\n OR<\/jats:styled-content>\n ) on either side of this inflection point were 3.71 (95%\n CI<\/jats:styled-content>\n : 2.87\u20134.79) on the left and 1.23 (95%\n CI<\/jats:styled-content>\n : 1.17\u20131.29) on the right, indicating a stronger correlation when\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C is below 1.42, particularly in younger individuals, females, and those with a\n BMI<\/jats:styled-content>\n under 25\u2009kg\/m\n 2<\/jats:sup>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C index shows a nonlinear positive correlation with\n NAFLD<\/jats:styled-content>\n risk, particularly when the\n TG<\/jats:styled-content>\n \/\n HDL<\/jats:styled-content>\n \u2010C ratio is below 1.42, with a stronger association observed in younger individuals, females, and lower\u2010BMI populations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.70107","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:09:13Z","timestamp":1758802153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nonlinear Relationship Between Triglyceride\u2010to\u2010High\u2010Density Lipoprotein Cholesterol Ratio and Non\u2010Alcoholic Fatty Liver Disease: A Secondary Retrospective Analysis Based on a Japanese Longitudinal Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Lingde","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Tuina Shenzhen Traditional Chinese Medicine Hospital (The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine) Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanfang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Tuina Shenzhen Traditional Chinese Medicine Hospital 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First Affiliated Hospital of Shenzhen University) Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2018-000869"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01319-2"},{"key":"e_1_2_12_4_1","first-page":"3579","article-title":"Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People With Non\u2010Alcoholic Fatty Liver Disease","volume":"13","author":"Hung M.","year":"2020","journal-title":"Diabetes Metabolic Syndrome and Obesity Targets and Therapy"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","unstructured":"T.OnayandA.U\u00e7ar \u201cWhich Anthropometric Measurement\/Ratio Is a Better Predictor of Non\u2010Alcoholic Fatty Liver Disease? \u201d (2023).","DOI":"10.21203\/rs.3.rs-2936765\/v1"},{"key":"e_1_2_12_6_1","unstructured":"G.Wen P.Qin X.Li 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