{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:56:11Z","timestamp":1793055371522,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2023\u2010JC\u2010YB\u2010741"],"award-info":[{"award-number":["2023\u2010JC\u2010YB\u2010741"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008209","name":"University at Buffalo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007258","name":"State University of New York","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007258","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Hemorrhagic fever with renal syndrome (\n HFRS<\/jats:styled-content>\n ) is an endemic disease occurring in various parts of the world. Prompt access to care with proper treatment is essential for preventing patients from developing renal failure and unfavorite outcomes. This study aimed to elucidate laboratory parameters associated with\n HFRS<\/jats:styled-content>\n severity and prognosis to predict disease course and initiate prompt clinical management.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective analysis of laboratory data was performed on\n HFRS<\/jats:styled-content>\n patients from December 2016 to January 2022 in Baoji City of Shaanxi Province in China using different statistical methods.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n WBC<\/jats:styled-content>\n and neutrophils in peripheral blood,\n RBC<\/jats:styled-content>\n in urine sediments, blood, protein, and glucose in urine,\n PT<\/jats:styled-content>\n \/\n INR<\/jats:styled-content>\n ,\n aPTT<\/jats:styled-content>\n ,\n TT<\/jats:styled-content>\n ,\n AST<\/jats:styled-content>\n ,\n ALT<\/jats:styled-content>\n ,\n AST<\/jats:styled-content>\n \/\n ALT<\/jats:styled-content>\n ,\n MAO<\/jats:styled-content>\n ,\n AD<\/jats:styled-content>\n , urea, creatinine, cystatin C,\n CK<\/jats:styled-content>\n \u2010\n MB<\/jats:styled-content>\n ,\n LDH<\/jats:styled-content>\n , \u03b1\u2010\n HBDH<\/jats:styled-content>\n ,\n mAST<\/jats:styled-content>\n , triglycerides, glucose, amylase, ferritin, and\n PCT<\/jats:styled-content>\n in serum increased in\n HFRS<\/jats:styled-content>\n patients along with disease severity, while the lymphocytes, monocytes, platelets, plateletcrit, fibrinogen, serum total protein, albumin,\n HDL<\/jats:styled-content>\n \u2010c, magnesium, complement\n C3<\/jats:styled-content>\n and\n C4<\/jats:styled-content>\n ,\n IgG<\/jats:styled-content>\n , triiodothyronine, thyroxine, and free triiodothyronine were reduced. Results also indicated that in uncured\n HFRS<\/jats:styled-content>\n patients, the\n NEUT<\/jats:styled-content>\n %,\n CRP<\/jats:styled-content>\n , cast,\n PT<\/jats:styled-content>\n \/\n INR<\/jats:styled-content>\n ,\n aPTT<\/jats:styled-content>\n , D\u2010dimer,\n AST<\/jats:styled-content>\n \/\n ALT<\/jats:styled-content>\n ,\n CK<\/jats:styled-content>\n \u2010\n MB<\/jats:styled-content>\n ,\n LDH<\/jats:styled-content>\n , \u03b1\u2010\n HBDH<\/jats:styled-content>\n , m\u2010\n AST<\/jats:styled-content>\n , ferritin, and\n PCT<\/jats:styled-content>\n were significantly higher than in cured patients, while platelets,\n C3<\/jats:styled-content>\n , and\n C4<\/jats:styled-content>\n in uncured patients were significantly lower than in cured patients. The\n NEUT<\/jats:styled-content>\n %,\n CRP<\/jats:styled-content>\n ,\n AST<\/jats:styled-content>\n \/\n ALT<\/jats:styled-content>\n , and\n LDH<\/jats:styled-content>\n were associated with patients' prognosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Laboratory data are helpful in predicting\n HFRS<\/jats:styled-content>\n patients' progress, severity, and prognosis, thus, these parameters are useful in guiding prompt clinical management of patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.70126","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:32:59Z","timestamp":1761625979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Laboratory Data Analysis of Hemorrhagic Fever With Renal Syndrome Patients to Predict Disease Severity and Patient 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