{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:27Z","timestamp":1786977987646,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Chronic kidney disease (CKD) constitutes one of the most important global health challenges and iron deficiency (ID) anemia is a frequent complication, especially in patients on dialysis.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This study aimed to assess differences in iron profile in dialysis\u2010adherent and non\u2010adherent chronic kidney disease subjects and analyze the profiles between both groups.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n One hundred and twenty patients undergoing hemodialysis were included in this cross\u2010sectional study, classified into two subcategories of dialysis adherence. The parameters of iron profile\u2014also defined as serum ferritin, transferrin saturation (TSAT), hemoglobin, and serum iron\u2014were studied. Multivariate regression analysis was carried out, adjusting for possible confounders such as age, sex, diabetes, and duration of dialysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Serum ferritin was significantly higher among adherent patients (235.6\u2009\u00b1\u2009120.2\u2009ng\/mL vs. 185.2\u2009\u00b1\u2009105.3\u2009ng\/mL;\n p<\/jats:italic>\n \u2009=\u20090.03), as were TSAT (33.4%\u2009\u00b1\u20099.3% vs. 28.8%\u2009\u00b1\u200910.2%;\n p<\/jats:italic>\n \u2009=\u20090.02) and hemoglobin (11.5\u2009\u00b1\u20091.8\u2009g\/dL vs. 10.2\u2009\u00b1\u20092.1\u2009g\/dL;\n p<\/jats:italic>\n \u2009=\u20090.04). Non\u2010adherence to the therapy was associated with a significantly higher number of patients having iron deficiency anemia (63% in non\u2010adherent vs. 40% in adherent patients;\n p<\/jats:italic>\n \u2009=\u20090.01). Multivariate analysis confirmed that dialysis adherence was independently associated with better iron status (\n p<\/jats:italic>\n \u2009<\u20090.05 for all parameters).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In hemodialysis patients, adherence to dialysis presents as a strong predictor of a better iron profile. Strategies that improve adherence to dialysis treatment by optimizing iron metabolism among chronic kidney disease patients should be in place.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.70132","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T10:04:12Z","timestamp":1764497052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iron Profile Variability in Hemodialysis Chronic Kidney Disease Patients"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6176-8935","authenticated-orcid":false,"given":"Collince Odiwuor","family":"Ogolla","sequence":"first","affiliation":[{"name":"Department of Applied Health Science, School of Health Science Kisii University Kisii Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7302-0374","authenticated-orcid":false,"given":"Lucy W.","family":"Karani","sequence":"additional","affiliation":[{"name":"Department of Applied Health Science, School of Health Science Kisii University Kisii Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanslaus","family":"Musyoki","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, School of Health Science South Eastern Kenya University Kitui Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phidelis","family":"Maruti","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, School of Health Science Kisii University Kisii Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150769"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.37"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.642296"},{"issue":"5","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.medcle.2020.07.022","article-title":"Anaemia of Chronic Diseases: Pathophysiology, Diagnosis and Treatment","volume":"156","author":"Cuevas Allende R.","year":"2021","journal-title":"Medicina Cl\u00ednica (English 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of Clinical Laboratory 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