{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:29:38Z","timestamp":1769736578143,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241052"],"award-info":[{"award-number":["82241052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acquired hemophilia A (AHA) is a rare hemorrhagic disease characterized by isolated prolongation of activated partial thromboplastin time (aPTT) and existence of autoantibodies against factor VIII (FVIII).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we present a patient with subcutaneous hemorrhage and remarkable prolongation of irreversible aPTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Further laboratory testing revealed reduced activity of multiple coagulation factors; this finding was subsequently identified as an artifact caused by the high\u2010titer FVIII inhibitor, confirmed through dilution studies. Despite the high inhibitor titer and the presence of bleeding manifestations, specific anti\u2010hemorrhagic therapy was not required for this patient. Following 6\u2009months of immunosuppressive treatment, the patient achieved resolution of ecchymosis and maintained normal coagulation factor activity. Throughout the 12\u2010month follow\u2010up period, the patient ultimately died from disease progression under palliative support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In all, this study demonstrated atypical characteristics of an AHA patient and emphasized that the treatment strategy should be guided by clinical manifestation rather than testing results solely.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70158","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:23:05Z","timestamp":1767770585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remarkable Prolongation of Irreversible\n                    <scp>APTT<\/scp>\n                    and Non\u2010Significant Hemorrhage: A Rare High Titer of\n                    <scp>FVIII<\/scp>\n                    Inhibitor Case Report and Literature Review"],"prefix":"10.1002","volume":"40","author":[{"given":"Ke\u2010Han","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u2010Song","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"Emergency Department Peking University People's Hospital  Beijing 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