{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:59Z","timestamp":1786978019334,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In South Korea, low\u2010resolution chromosomal microarray analysis (LR\u2010CMA) is frequently used as a screening tool to identify chromosomal anomalies in asymptomatic newborns. However, its clinical utility remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 99 asymptomatic newborns who underwent diagnostic CMA following abnormal LR\u2010CMA screening results at a single tertiary hospital between 2019 and 2024. Clinical features, copy number variant (CNV) findings, and follow\u2010up outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 99 patients (57.6% male), the median ages at the initial and last visits were 0.3 and 1.0\u2009years, respectively. A total of 171 CNVs were identified, of which 85 (49.7%) were classified as pathogenic or likely pathogenic. Overall, 70 of 99 (70.7%) patients harbored microduplication or deletions with syndromic implications. Developmental delay was identified in 10 (10.1%) patients. Notably, no significant associations were found between CNV pathogenicity and prenatal history, presence of anomalies, developmental delays, or growth parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although a high rate of clinically significant CNVs was detected through LR\u2010CMA screening, only a minority of asymptomatic newborns exhibited developmental concerns within the observed follow\u2010up period. These findings suggest that while LR\u2010CMA may identify genetic alterations of interest, its routine use in asymptomatic newborns warrants careful consideration of clinical relevance and potential psychosocial impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70160","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:23:46Z","timestamp":1767338626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Genetic Significance of Chromosomal Microarray Screening of Asymptomatic Newborns"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-9608","authenticated-orcid":false,"given":"Naye","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-5315","authenticated-orcid":false,"given":"Hwa Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Pediatrics Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-7828","authenticated-orcid":false,"given":"Jung Min","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"},{"name":"Department of Pediatrics Seoul National University College of Medicine  Seoul South Korea"},{"name":"Rare Disease Center Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010018\u20100244\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010020\u201000707\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2018.61.5.135"},{"key":"e_1_2_10_7_1","unstructured":"GC Genome \u201ci\u2010Screen (Newborn Genome Screening) \u201daccessed May 21 2025 https:\/\/gc\u2010genome.com\/preneo\u2010natal\/i\u2010screen\/."},{"key":"e_1_2_10_8_1","unstructured":"LabGenomics \u201cEnfantGuard \u201daccessed May 21 2025 https:\/\/enfantguard.com\/bbs\/page.php?hid=m02_02."},{"key":"e_1_2_10_9_1","unstructured":"Dx&Vx \u201cGenomeCheck M \u201daccessed May 21 2025 https:\/\/www.dxvx.com\/eng\/product\/dxProduct.php."},{"key":"e_1_2_10_10_1","unstructured":"EDGC \u201cGscanning \u201daccessed May 21 2025 https:\/\/www.edgc.com\/eng\/bbs\/content.php?co_id=prd_type12."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182217a3a"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010021\u201001150\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181f8baad"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2471\/blt.07.050112"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.2174"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.10.016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805384"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35969"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38247"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009319\u20108"},{"key":"e_1_2_10_21_1","volume-title":"Charcot\u2010Marie\u2010Tooth Disease","author":"Nagappa M.","year":"2024"},{"key":"e_1_2_10_22_1","volume-title":"StatPearls","author":"Thada P. 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