{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:39:43Z","timestamp":1772987983367,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Diabetic Foot Ulcers (DFUs) represent a prevalent and serious complication of diabetes, frequently resulting in persistent wounds and delayed healing. This research explores the healing effects of mesenchymal stem cells (MSCs) on DFUs and examines the involvement of Notch signaling in this therapeutic process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BALB\/c mice were induced with diabetes using streptozotocin (STZ) and divided into five groups: Control, Model, MSCs Treatment, MSCs\u2009+\u2009Notch Inhibition, and MSCs\u2009+\u2009Notch Activation. Wound healing was monitored, and tissue samples were analyzed using histological and molecular techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrated that MSCs treatment significantly accelerated wound healing, as evidenced by improved histopathology and enhanced expression of CD31, VEGF, FGF, and PECAM\u20101 in MSCs\u2010treated groups. Notch activation further enhanced MSCs\u2010mediated healing, as shown by increased Notch1 and Jagged\u20101 protein levels. Conversely, the MSCs\u2009+\u2009Notch Inhibition Group showed reduced healing and similar results to the Model Group, with lower expression of Notch1 and Jagged\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that MSCs promote DFU healing, and Notch signaling plays a crucial role in enhancing MSC\u2010mediated repair. Our results highlight the potential of MSC\u2010based therapies combined with Notch pathway modulation as a promising strategy for improving DFU treatment and wound healing in diabetic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70162","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:06:57Z","timestamp":1769065617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal Stem Cell\u2010Mediated Vascular Regeneration in Diabetic Foot Ulcers via the Notch Signaling Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Feifei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery and Interventional Surgery Chongming Hospital, Shanghai Health Medical College  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Chongming Hospital, Shanghai Health Medical College  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6648-4612","authenticated-orcid":false,"given":"Xin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Interventional Surgery Chongming Hospital, Shanghai Health Medical College  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chongming Hospital, Shanghai Health Medical College  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-0625","authenticated-orcid":false,"given":"Jingming","family":"Ou","sequence":"additional","affiliation":[{"name":"Interventional Vascular Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Interventional Surgery Chongming Hospital, Shanghai Health Medical College  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Interventional Surgery Chongming Hospital, Shanghai Health Medical College  Shanghai 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