{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:15:08Z","timestamp":1773929708820,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170123"],"award-info":[{"award-number":["82170123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH132"],"award-info":[{"award-number":["ZR2021MH132"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with complex immunopathogenesis. Its major symptoms, such as bleeding tendency and fatigue, may predispose patients to depression and anxiety. Although psychiatric comorbidities are increasingly recognized in ITP management, whether ITP causally contributes to these conditions remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a two\u2010sample Mendelian randomization (MR) study to investigate the potential genetically causal links between ITP and depression\/anxiety. To ensure robustness, complementary MR approaches were performed, including pleiotropy\u2010robust methods (MR\u2010Corr and MRMix), multivariable MR adjusting for inflammatory biomarkers (C\u2010reactive protein and interleukin\u20106), the robust adjusted profile score (RAPS) model, reverse MR, and colocalization analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MR analysis revealed a positive causal effect of ITP on depression (OR\u2009=\u20091.007, 95% CI: 1.001\u20131.013;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), whereas no genetic predisposition of ITP on anxiety was observed. Multivariable and pleiotropy\u2010robust sensitivity analyses supported the stability and consistency of the ITP\u2010depression association, indicating that the result was unlikely driven by pleiotropy, instrument weakness, or inflammatory confounding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provided novel genetic evidence supporting ITP\u2010associated mental health issues and highlighted the importance of integrated psycho\u2010hematological interventions for ITP in clinical practice. Future research was needed to elucidate the biological underpinning between ITP and psychiatric disorders, which might provide more options for ITP patients to improve life quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70176","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:06:22Z","timestamp":1770815182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Genetic Link Between Primary Immune Thrombocytopenia and Depression\/Anxiety Disorders: A Two\u2010Sample Mendelian Randomization Study"],"prefix":"10.1002","volume":"40","author":[{"given":"Le","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou\u2010qing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010yu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hematology North China University of Science and Technology Affiliated Hospital  Tangshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-4498","authenticated-orcid":false,"given":"Xin\u2010guang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01401-z"},{"issue":"5","key":"e_1_2_12_3_1","first-page":"369","article-title":"A Physician\u2010Patient Survey for Primary Immune Thrombocytopenia: Chinese Subgroup Analysis of I\u2010WISh International Survey","volume":"42","author":"Wang R. 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