{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:08:15Z","timestamp":1784304495619,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study assessed the diagnostic value of complete blood count (CBC) and derived immune\u2010inflammatory indicators for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      <\/jats:styled-content>\n                      pneumonia (MPP) in children and developed a practical scoring system for early diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 1662 MP\u2010infected children were divided into pneumonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009844) and non\u2010pneumonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009818) groups. CBC parameters, derived immune\u2010inflammatory indicators and C\u2010reactive protein (CRP) were compared. Diagnostic performance was assessed using ROC curve analysis, and diagnostic models were constructed using multivariate logistic regression. Age\u2010stratified analysis addressed confounding. Model stability was evaluated via repeated stratified 10\u2010fold cross\u2010validation, calibration curves with Brier score, and decision curve analysis (DCA). A simplified scoring system was established and validated for clinical application.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children in the pneumonia group were significantly younger (mean age 5.78\u2009\u00b1\u20093.41\u2009years vs. 8.62\u2009\u00b1\u20094.92\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Lymphocyte count (LYM), lymphocyte percentage (LYM%), platelet count (PLT), plateletcrit (PCT), and the product of absolute lymphocyte count and platelet count (PLT\u2009\u00d7\u2009LYM) in the pneumonia group were significantly higher than in the non\u2010pneumonia group. Age\u2010stratified analysis confirmed these differences across all age subgroups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). PLT\u2009\u00d7\u2009LYM, LYM%, PLT, and PCT were independent predictors. Internal validation showed a mean AUC of 0.7824\u2009\u00b1\u20090.0353, good calibration (Brier score\u2009=\u20090.1918\u2009\u00b1\u20090.0164), and positive net benefit on DCA. The scoring system achieved diagnostic rates of 71.5%, 51.2%, and 29.6% for high\u2010, medium\u2010, and low\u2010risk groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MPP predominantly affects children under 7\u2009years old. The simple scoring system, supported by robust internal validation, effectively stratifies pneumonia risk and offers a practical early diagnostic tool for primary care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70263","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T13:10:30Z","timestamp":1780751430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of a Combined Diagnostic and Severity Scoring System Based on Complete Blood Count and Derived Immune\u2010Inflammatory Indicators in Children With\n                    <i>Mycoplasma pneumoniae<\/i>\n                    Pneumonia"],"prefix":"10.1002","volume":"40","author":[{"given":"Quan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Huaibei People's Hospital (Huaibei People's Hospital Attached to Bengbu Medical University)  Huaibei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Huaibei People's Hospital (Huaibei People's Hospital Attached to Bengbu Medical University)  Huaibei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Huaibei People's Hospital (Huaibei People's Hospital Attached to Bengbu Medical University)  Huaibei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Mei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Huaibei People's Hospital (Huaibei People's Hospital Attached to Bengbu Medical University)  Huaibei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Huaibei People's Hospital (Huaibei People's Hospital Attached to Bengbu Medical University)  Huaibei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1650-5994","authenticated-orcid":false,"given":"Ling","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Huaibei People's Hospital (Huaibei People's Hospital Attached to Bengbu Medical University)  Huaibei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05519-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00406-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13620"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-025-01829-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000254"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-23-435"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-24-172"},{"issue":"12","key":"e_1_2_9_9_1","first-page":"1137","article-title":"The Society of Pediatrics, Chinese Medical Association; China National Clinical Research Center of Respiratory Diseases; Editorial Board, Chinese Journal of Pediatrics","volume":"62","author":"Subspecialty Group of Respiratory","year":"2024","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.25150"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144584"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S479660"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040628"},{"issue":"2","key":"e_1_2_9_14_1","article-title":"Mycoplasma pneumoniae\n                   Epidemic in Denmark, October to December, 2023","volume":"29","author":"Nordholm A. 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