{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:07:10Z","timestamp":1784304430919,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100030944","name":"Korea Association of Health Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated longitudinal changes in the serum pepsinogen (PG) I\/II ratio according to endoscopic gastric mucosal atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 21,265 participants who underwent endoscopy during health checkups between 2015 and 2023. Longitudinal changes in PG I\/II ratio were examined in 2217 subjects with \u2265\u20092 endoscopies using linear mixed\u2010effects models. Serum PG I, PG II, and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      IgG were measured. The AG severity was graded endoscopically according to Kimura\u2013Takemoto classification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PG I\/II ratio decreased stepwise with advancing Kimura\u2010Takemoto stage. In longitudinal analyses of 2217 participants with repeated endoscopy, within\u2010subject declines in the PG I\/II ratio paralleled progression of endoscopic atrophy, with greater reductions in more advanced stages (No atrophy: reference; C2: \u22120.383; C3: \u22121.150; O1: \u22121.412; O2: \u22122.101; O3: \u22122.007; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within\u2010subject declines in the PG I\/II ratio were observed with progression of gastric atrophy. Serial measurement of the PG I\/II ratio may be useful for monitoring the progression of gastric mucosal atrophy, particularly in patients for whom repeated endoscopic evaluation is not feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70264","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:04:42Z","timestamp":1779703482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Changes in the Serum Pepsinogen I\/\n                    <scp>II<\/scp>\n                    Ratio With Progression of Gastric Atrophy"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-1534","authenticated-orcid":false,"given":"Soie","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center  Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center  Seoul Republic of Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/0969141041732184"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200308000-00007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.12.3825"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1511-x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e117"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0506-22"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16488"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19091"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.05.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1686058"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63928-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5903"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20200618"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i46.13113"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06474.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2019.072"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.70264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.70264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.70264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:40:51Z","timestamp":1784302851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.70264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":20,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jcla.70264"],"URL":"https:\/\/doi.org\/10.1002\/jcla.70264","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70264"}}