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Dysregulated lipid metabolism has been observed in various cancer types, and this metabolic rewiring facilitates tumor growth, metastasis, and treatment resistance. Additionally, aberrant lipid metabolism is associated with poor patient prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review aims to provide a comprehensive overview of cancer metabolism, with a specific focus on lipid metabolism\/lipogenesis and its association with resistance to third\u2010generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR\u2010TKIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lipid metabolism\/lipogenesis provides cancer cells with energy substrates and building blocks for membrane biogenesis. In parallel, resistance to third\u2010generation EGFR\u2010TKIs has emerged as a major challenge in the treatment of non\u2010small cell lung cancer (NSCLC) driven by EGFR mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding the intricate connections between lipid metabolism\/lipogenesis and resistance to third\u2010generation EGFR\u2010TKIs is crucial for developing effective therapeutic strategies. Targeting lipid metabolism pathways holds promise as a novel therapeutic approach to overcome treatment resistance and improve patient prognosis. Further research is needed to better understand the underlying mechanisms and identify potential drug targets in lipid metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70274","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:30:07Z","timestamp":1780504207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR\u2010TKIs"],"prefix":"10.1002","volume":"40","author":[{"given":"Wenhao","family":"Luo","sequence":"first","affiliation":[{"name":"School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zun","family":"Wang","sequence":"additional","affiliation":[{"name":"West China School of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-2901","authenticated-orcid":false,"given":"Wang","family":"Shen","sequence":"additional","affiliation":[{"name":"Lung Cancer Center West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affliliated Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yida","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Provincial People's Hospital 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