{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:58:44Z","timestamp":1785373124695,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72274218"],"award-info":[{"award-number":["72274218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study utilized two indirect methods to establish reference intervals (RIs) for four coagulation parameters for the adult population in Tibet, a high\u2010altitude region in Western China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Coagulation Data, Including Activated Partial Thromboplastin Time (APTT), prothrombin Time (PT), thrombin Time (TT), and Fibrinogen (FIB) Obtained From the People's Hospital of Tibet Autonomous Region Between 2019 and 2023, Were Subjected to Box\u2010Cox Transformation for Normalization and Tukey Method for Outlier Removal. the RIs Were Calculated Using Hoffmann and refineR Methods, Respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 5086, 5282, 5386, and 5377 test results for APTT, PT, TT, and FIB were included. The Hoffmann and refineR method yielded the following total RIs: APTT 30.54\u201346.32 and 30.14\u201344.30\u2009s; PT 10.54\u201314.51 and 10.32\u201313.89\u2009s; TT 14.92\u201319.46 and 14.88\u201318.93\u2009s; FIB 2.05\u20134.68 and 2.02\u20134.40\u2009g\/L, respectively. Gender\u2010partitioned RIs were calculated for all four parameters, while age\u2010partitioned RIs were specifically calculated for PT and FIB based on bias ratio values. The lower limits of RIs estimated by the two methods remained consistent. The established RIs for APTT and FIB were significantly higher than those utilized in the plain area and those provided by the manufacturer, whereas the established RIs of TT were significantly lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The RIs for coagulation parameters in the population living on the Tibetan Plateau exhibited significant divergence from those utilized in the plain area. Specific RIs for high\u2010altitude regions should be established to accurately evaluate the presence of coagulation disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70287","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:53:32Z","timestamp":1782140012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reference Interval Establishment for Four Coagulation Parameters Using Indirect Methods in a High\u2010Altitude Chinese Population: A Retrospective Real\u2010World Analysis"],"prefix":"10.1002","volume":"40","author":[{"given":"Banjiu","family":"Zhaxi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Peking Union Medical College Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Science  Beijing 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