{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:03:23Z","timestamp":1789653803867,"version":"4.0.0"},"reference-count":16,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the relationship between active uveitis and hematological inflammation indices, specifically the HALP and CALLY scores, in patients with ankylosing spondylitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross\u2010sectional study included 140 patients with AS. The patients were divided into two groups based on the presence of uveitis. Laboratory data obtained during active uveitis episodes were used for the uveitis group, while routine follow\u2010up data were used for the control group. Hematological inflammation indices were calculated and appropriate statistical analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with uveitis, NLR, PLR, SII, and AISI values were found to be significantly higher, while HALP and CALLY scores were significantly lower (all remaining significant after Benjamini\u2010Hochberg FDR correction). SIRI and MLR did not retain significance after FDR correction. In the ROC analysis, the HALP and CALLY indices demonstrated moderate discriminatory performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although hematological inflammation indices are associated with the presence of uveitis, they have limited value for diagnostic purposes alone. In clinical practice, however, they may serve as complementary markers for assessing inflammatory burden in patients with AS and may provide supportive information when evaluating active uveitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70316","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:40:26Z","timestamp":1785292826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematological Inflammation Indices Are Associated With Active Uveitis in Ankylosing Spondylitis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-4716","authenticated-orcid":false,"given":"Mesude Seda","family":"Aydo\u011fdu","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Malatya Turgut \u00d6zal University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-9618","authenticated-orcid":false,"given":"Zarife Ekici","family":"G\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Malatya Turgut \u00d6zal University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042012000500009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21908"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1646276"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0992-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum\/196066"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"74","article-title":"Assessment of Hematologic Indices for Diagnosis in Juvenile Systemic Lupus Erythematosus","volume":"62","author":"Baykal G. \u00d6.","year":"2024","journal-title":"Reumatologia"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5629"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-51109-w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.54005\/geneltip.1331223"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20240068"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.38053\/acmj.1725787"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.51271\/KMJ-0183"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.18621\/eurj.1609765"},{"key":"e_1_2_10_16_1","first-page":"1","article-title":"HALP Score and Disease Activity in Psoriatic Arthritis: Comparison With Healthy Controls","volume":"12","author":"Zontul S.","year":"2026","journal-title":"European Research Journal"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195525"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.70316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.70316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.70316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:16:32Z","timestamp":1789650992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.70316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":16,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jcla.70316"],"URL":"https:\/\/doi.org\/10.1002\/jcla.70316","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"2026-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70316"}}