{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:58:35Z","timestamp":1790686715128,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A671041"],"award-info":[{"award-number":["N42A671041"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early detection of Chronic Kidney Disease (CKD) is essential for preventing disease progression, with microalbuminuria serving as a key marker for renal impairment. While conventional laboratory methods are accurate, they often come with high costs and long turnaround times. Our research group previously developed the point\u2010of\u2010care (PoC) MyACR device for determining urine albumin\u2010to\u2010creatinine ratios. Building on this, we introduced My\u03bcAlbumin, a PoC, high\u2010precision immunoturbidimetric device designed for rapid, real\u2010time quantification of urinary albumin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The My\u03bcAlbumin system uses a 340\u2009nm UV LED and an integrated microcontroller to measure turbidity from specific antigen\u2013antibody interactions. Clinical validation was performed on urine samples from 138 patients at risk for CKD, with device performance compared to a hospital\u2010grade immunoturbidimetric reference method through Spearman's correlation and Bland\u2013Altman analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The My\u03bcAlbumin device demonstrated exceptional diagnostic accuracy, with a sensitivity of 99.11% and a specificity of 98.23%. It maintained a strong linear correlation (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.9925) across a concentration range of 0\u20131000\u2009mg\/L, with Bland\u2013Altman analysis showing high agreement with the reference method (mean bias of 0.57\u2009mg\/L). Urinary albumin levels correlated significantly with elevated blood urea nitrogen (BUN) and serum creatinine. Clinical analysis indicated that microalbuminuria was more prevalent among older patients with diabetes, hypertension, and CKD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The My\u03bcAlbumin device significantly advances PoC testing, surpassing conventional tools in sensitivity and specificity. Its rapid, laboratory\u2010grade results enhance clinical decision\u2010making, making it a transformative tool for early CKD screening in primary care and resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70322","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:12:02Z","timestamp":1785244322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From MyACR to My\u03bcAlbumin: Clinical Validation of a High\u2010Precision, Real\u2010Time Immunoturbidimetric PoC Device for Early Chronic Kidney Disease Detection"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4856-0555","authenticated-orcid":false,"given":"Tullayakorn","family":"Plengsuriyakarn","sequence":"first","affiliation":[{"name":"Center of Excellence in Molecular Biology and Pharmacology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanna","family":"Chaijaroenkul","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Pharmacology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napaporn","family":"Youngvises","sequence":"additional","affiliation":[{"name":"The Office of Advanced Science and Technology Thammasat University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kridsada","family":"Sirisabhabhorn","sequence":"additional","affiliation":[{"name":"Department of Medical Technology Laboratory Thammasat Chalermprakiet Hospital  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waraporn","family":"Bubpha","sequence":"additional","affiliation":[{"name":"Department of Medical Technology Laboratory Thammasat Chalermprakiet Hospital  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6389-0897","authenticated-orcid":false,"given":"Kesara","family":"Na\u2010Bangchang","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Pharmacology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"},{"name":"The Office of Advanced Science and Technology Thammasat University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"e_1_2_11_3_1","volume-title":"Global Kidney Health Atlas: A Report by the International Society of Nephrology on the Global Burden of End\u2010Stage Kidney Disease and Capacity for Kidney Care","author":"International Society of 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