{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:00:15Z","timestamp":1790661615532,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis is a life\u2010threatening condition associated with high mortality, and current biomarkers remain suboptimal in prognostic evaluation. This study aimed to explore the associations of whole blood methyltransferase\u2010like 7B (METTL7B) expression with disease severity and 28\u2010day mortality in sepsis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study (93 sepsis patients, 22 non\u2010septic ICU controls), whole blood METTL7B (RT\u2010qPCR) and conventional biomarkers (SOFA, PCT, CRP, IL\u20106) were measured. Dynamic SOFA changes (\u0394SOFA from admission to Day 7) were assessed. ROC curves, logistic regression, and a combined model were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      METTL7B levels were significantly elevated in sepsis patients compared to non\u2010septic controls (5.6\u2009\u00b1\u20091.33 vs. 2.44\u2009\u00b1\u20090.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with higher levels observed in non\u2010survivors. Baseline METTL7B levels were significantly higher in patients with a deteriorating SOFA trajectory (\u0394SOFA \u2265 +2) compared to those with stable or improving courses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The AUC for METTL7B alone in predicting 28\u2010day mortality was 0.779, outperforming CRP and IL\u20106. The combination of METTL7B with SOFA and PCT achieved the highest predictive accuracy (AUC\u2009=\u20090.854). Multivariate logistic regression identified METTL7B as associated with disease severity and 28\u2010day mortality risk in patients with sepsis (OR\u2009=\u20091.928,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated whole blood METTL7B expression is associated with disease severity and unfavorable outcomes in septic patients. When combined with dynamic SOFA and PCT, it improves prognostic stratification. These findings suggest its potential value as a severity\u2010associated complementary marker warranting multi\u2010center validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70366","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:21:48Z","timestamp":1790659308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>METTL7B<\/scp>\n                    Expression in Sepsis: Association With Disease Severity and 28\u2010Day Mortality"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9820-4321","authenticated-orcid":false,"given":"Yuxuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency The Affiliated Chengdu 363 Hospital of Southwest Medical University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-4002","authenticated-orcid":false,"given":"Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"10141","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and Septic Shock","volume":"392","author":"Cecconi M.","year":"2018","journal-title":"Lancet"},{"issue":"10219","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, Regional, and National Sepsis Incidence and Mortality, 1990\u20102017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd K. 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