{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:53:32Z","timestamp":1791190412296,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Routine urinalysis is a foundational screening tool; however, increased hyaline casts accompanied by a negative dipstick protein result may complicate laboratory interpretation. In patients at high risk of acute kidney injury (AKI), this discordant pattern may warrant confirmatory protein testing and correlation with renal\u2010function trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A 31\u2010year\u2010old female with hemophagocytic lymphohistiocytosis (HLH) underwent routine urinalysis after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Automated sediment analysis detected elevated hyaline casts (5.8\/\u03bcL), whereas the concurrent dipstick protein result was negative. Protocol\u2010based sulfosalicylic acid (SSA) verification yielded a visually graded positive (++) reaction. Serial renal\u2010function monitoring showed that serum creatinine (SCr) increased from 53\u2009\u03bcmol\/L on December 10 to 62\u2009\u03bcmol\/L on December 12, followed by progressive deterioration and a peak SCr of 132\u2009\u03bcmol\/L with an estimated glomerular filtration rate (eGFR) nadir of 46.3\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      on December 24. Follow\u2010up urinalysis on December 26 showed normalization of this urinary phenotype, with negative dipstick protein, negative SSA testing, and a decrease in hyaline casts to 0.5\/\u03bcL. These findings were consistent with a transient urinary abnormality occurring during evolving AKI rather than persistent kidney disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this high\u2010risk post\u2010transplant patient, increased hyaline casts with negative dipstick protein and positive SSA testing occurred during evolving AKI and resolved as renal function improved. The finding may indicate acid\u2010precipitable non\u2010albumin urinary material, but its molecular basis and relationship to tubular injury remain uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.70376","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:11:11Z","timestamp":1791187871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discrepant Urinary Findings Between Dipstick Protein and Sulfosalicylic Acid Test in a Patient With Hyaline Casts: A Case Report"],"prefix":"10.1002","author":[{"given":"Yifei","family":"Jia","sequence":"first","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binquan","family":"Chu","sequence":"additional","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjun","family":"Chen","sequence":"additional","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9931-5761","authenticated-orcid":false,"given":"Chen","family":"Hang","sequence":"additional","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Yu","sequence":"additional","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1390-7129","authenticated-orcid":false,"given":"Jinpiao","family":"Lin","sequence":"additional","affiliation":[{"name":"The Clinical Laboratory of Shanghai Tongren Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"156","volume-title":"Fundamentals of Clinical Laboratory Science","author":"Cong Y. 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