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Because bipolar disorder is characterized by high degrees of comorbidity and high rates of medical complications, the clinician will frequently need to implement other treatments targeted to comorbid conditions, such as panic, generalized anxiety, substance abuse, and personality disorders. This article introduces the issue of <jats:italic>Journal of Clinical Psychology: In Session<\/jats:italic> devoted to the treatment of bipolar disorder. We describe the cognitive styles and personal vulnerabilities that pose greater risk for bipolar disorder. Three evidence\u2010based psychological treatments (interpersonal social rhythm therapy, family\u2010focused treatment, and cognitive\u2010behavioral therapy) and current pharmacological treatments are examined and illustrated. Finally, we review the effectiveness and practice implications of a variety of treatments for this severe and underresearched disorder. \u00a9 2007 Wiley Periodicals, Inc. 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