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Using a prospective single\u2010case experimental design, the patient provided mood ratings every 4 hours and sleep reports daily for 49 weeks, including a 4\u2010week baseline, a 20\u2010session CBT intervention, and a follow\u2010up period. Improvements in mood during and after therapy were accounted for by reduced daily mood variability and extended sleep. The patient's energy at different times of day was explained by adjusting the endogenous rhythm in a mathematical circadian model. Treatment of cyclothymia and related bipolar disorders may be enhanced by integrating understanding of circadian mood regulation into CBT treatment. \u00a9 2008 Wiley Periodicals, Inc. 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