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We summarize the meta\u2010analytic results and clinical practices on the adaptations of psychotherapy to multiple transdiagnostic characteristics of the patient, including attachment style, culture (race\/ethnicity), gender identity, coping style, therapy preferences, reactance level, religion and spirituality, sexual orientation, and stages of change. We then discuss the clinical and research process of determining what works, and what does not work, for whom. The limitations of the Task Force\u2019s work are outlined and frequently asked questions are addressed. The article closes with the Task Force\u2019s formal conclusions and 28 recommendations and with some reflections on fitting psychotherapy to the individual client.<\/jats:p>","DOI":"10.1002\/jclp.22678","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T08:45:18Z","timestamp":1539852318000},"page":"1889-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["A new therapy for each patient: Evidence\u2010based relationships and responsiveness"],"prefix":"10.1002","volume":"74","author":[{"given":"John C.","family":"Norcross","sequence":"first","affiliation":[{"name":"Department of Psychology University of Scranton Scranton USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Wampold","sequence":"additional","affiliation":[{"name":"Department of Counseling Psychology, Modum Bad Psychiatric Center, University of Wisconsin\u2010Madison Madison USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"e_1_2_15_1_2_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1037\/0003-066X.61.4.271","article-title":"Evidence\u2010based practice in psychology","volume":"61","author":"American Psychological Association Task Force on Evidence\u2010Based Practice","year":"2006","journal-title":"American Psychologist"},{"key":"e_1_2_15_1_3_1","volume-title":"Effective psychotherapy: A handbook of research","author":"Auerbach A. 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