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We present a series of systematic reviews and meta\u2010analyses examining four psychiatric disorders frequently associated with OCD\u2014depression, bipolar disorder, substance abuse disorder and psychosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three electronic databases were searched up to May 2017; PsycINFO, Medline, and Web of Science. Meta\u2010analyses using random effects models were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analyses found strong associations between all comorbidities and OCD, particularly for depression. In addition, a series of systematic reviews were conducted giving information about the characteristics of these psychiatric associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is probable that these disorders share common etiological factors, and thus trans\u2010diagnostic processes must be addressed when offering treatment. Clinical implications of these findings are discussed with suggestions for further research in the area.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jclp.23240","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:19:56Z","timestamp":1630934396000},"page":"469-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Psychiatric comorbidities of obsessive\u2010compulsive disorder: A series of systematic reviews and meta\u2010analyses"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-5007","authenticated-orcid":false,"given":"Charlotte","family":"Rowe","sequence":"first","affiliation":[{"name":"Laboratoire de Psychologie des Pays de la Loire LPPL\u2010EA4638, Facult\u00e9 de Psychologie Universit\u00e9 de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-3163","authenticated-orcid":false,"given":"Aurore","family":"Deledalle","sequence":"additional","affiliation":[{"name":"Laboratoire de Psychologie des Pays de la Loire LPPL\u2010EA4638, Facult\u00e9 de Psychologie Universit\u00e9 de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-0396","authenticated-orcid":false,"given":"Abdel Halim","family":"Boudoukha","sequence":"additional","affiliation":[{"name":"Laboratoire de Psychologie des Pays de la Loire LPPL\u2010EA4638, Facult\u00e9 de Psychologie Universit\u00e9 de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-010-0337-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/npa.2015.7657"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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