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The current study sought to examine whether intolerance of uncertainty and its subfactors mediate the relationship between social interaction anxiety and the tendency to interpret positive social events negatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>One hundred and sixty\u2010five individuals with social anxiety disorder completed measures of social interaction anxiety symptom severity, intolerance of uncertainty, and negative interpretations of positive social events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total intolerance of uncertainty and the inhibitory\u2010intolerance of uncertainty subscale scores significantly mediated the relationship between social interaction anxiety and negative interpretations of positive events. Exploratory post\u2010hoc analyses regarding the possible contributing role of depression demonstrated mixed results. The same mediation pattern was found in the full sample as well as those without a secondary comorbid mood disorder diagnosis. In contrast, serial mediation showed a mediating role of depressive symptom severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inhibitory\u2010intolerance of uncertainty plays a role in the relationship between social interaction anxiety and negative interpretations of positive social events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jclp.23363","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T14:21:33Z","timestamp":1650291693000},"page":"2513-2524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Social anxiety and negative interpretations of positive social events: What role does intolerance of uncertainty play?"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-331X","authenticated-orcid":false,"given":"Yasunori","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Campbell Family Mental Health Research Institute Center for Addiction and Mental Health Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-4777","authenticated-orcid":false,"given":"Katie","family":"Fracalanza","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-132X","authenticated-orcid":false,"given":"Neil A.","family":"Rector","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2749-9783","authenticated-orcid":false,"given":"Judith M.","family":"Laposa","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute Center for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2007.05.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2017.08.002"},{"key":"e_1_2_12_4_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association (APA)","year":"2000"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2012.08.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.07.009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(96)00068-X"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2016.02.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.03.014"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.07.121"},{"key":"e_1_2_12_11_1","first-page":"69","volume-title":"Social phobia: Diagnosis, assessment, and treatment","author":"Clark D. 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