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Finally, the mediating role of emotional dysregulation as a core process in the effect of interventions on anxiety\u2010depressive and stress symptoms was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and seventy\u2010nine individuals aged 18\u201368 years (<jats:italic>M<\/jats:italic>\u2009=\u200939, SD\u2009=\u200912.4; 83.9% females) with emotion regulation difficulties were randomly assigned to one of the three 12\u2010weeks online programs: Compassion Focused Program (CFP), an Emotional Competencies Program (ECP) or a Waitlist control condition (WL). Participants completed pre\u2010, post\u2010 and 3 months follow\u2010up measures of each outcome. Mixed effect linear models compared groups on primary and secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that (1) perceived credibility and expectancy and satisfaction did not differ between the two interventions, (2) both interventions reduced emotion regulation difficulty, depression, anxiety and stress symptoms, and enhanced well\u2010being, self\u2010compassion, and emotional competencies; (3) ECP was more effective to enhance well\u2010being than CFP; (4) CFP was more effective to enhance emotional competencies than ECP, and (5) emotion regulation difficulty mediated the effect of the interventions on depression, anxiety, and stress symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings offer preliminary support for the usefulness of online CFP and ECP to reduce emotion dysregulation, symptoms of depression, anxiety, and stress and to increase well\u2010being, self\u2010compassion and emotional competencies. 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