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This meta\u2010analytic review aims to summarize the associations between interpersonal problems and multiple domains of mental health based on naturalistic, observational data from both clinical and nonclinical populations. Focusing on studies using the Inventory of Interpersonal Problems (IIP), we examined the cross\u2010sectional associations between interpersonal problems and general psychological distress, depressive symptoms, symptoms of anxiety, positive and negative emotions, well\u2010being, and perceived stress. A three\u2010level meta\u2010analytic model was employed to account for the nested data structure, and moderator analyses examined differences between clinical and nonclinical samples. Across all domains, 120 effect sizes from 66 studies were included. Significant positive correlations emerged between interpersonal problems and general psychological distress (<jats:italic>r<\/jats:italic>\u2009=\u20090.565, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), depression (<jats:italic>r<\/jats:italic>\u2009=\u20090.473, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), anxiety (<jats:italic>r<\/jats:italic>\u2009=\u20090.454, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and negative emotions (<jats:italic>r<\/jats:italic>\u2009=\u20090.486, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In contrast, significant negative correlations were found with positive emotions (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.224, <jats:italic>p<\/jats:italic>\u2009=\u20090.010) and well\u2010being (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.372, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). There were too few studies available to meta\u2010analyze perceived stress. Clinical status did not significantly moderate these associations, suggesting that the observed associations are relatively consistent across populations. These findings underscore the relevance of interpersonal problems, as measured by the IIP, for understanding mental health and provide evidence\u2010based estimates of these associations.<\/jats:p>","DOI":"10.1002\/jclp.70022","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T03:08:46Z","timestamp":1754363326000},"page":"1046-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Interpersonal Problems and Their Mental Health Correlates: A Meta\u2010Analytic Review"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-0377","authenticated-orcid":false,"given":"Flavio","family":"Iovoli","sequence":"first","affiliation":[{"name":"Department of Psychology Osnabrueck University Osnabrueck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-6611","authenticated-orcid":false,"given":"Julian A.","family":"Rubel","sequence":"additional","affiliation":[{"name":"Department of Psychology Osnabrueck University Osnabrueck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0434-2870","authenticated-orcid":false,"given":"Tobias","family":"Steinbrenner","sequence":"additional","affiliation":[{"name":"Department of Psychology Osnabrueck University Osnabrueck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0101-0264","authenticated-orcid":false,"given":"Ruben","family":"Lauterbach","sequence":"additional","affiliation":[{"name":"Department of Medicine Justus\u2010Liebig\u2010University Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5350\/DAJPN2016290104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00223891.1990.9674088"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315129556"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.20982\/tqmp.12.3.p154"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/bec.2018.19"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1026\/1616-3443.34.3.205"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20375"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2021.104011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6811.00033"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17121383"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0032968"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211882"},{"key":"e_1_2_10_16_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptr\/kpg007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00332747.1976.11023874"},{"key":"e_1_2_10_20_1","volume-title":"SCL\u201090\u2010R, Administration, Scoring & Procedures Manual\u2010I for the R(evised) Version","author":"Derogatis L. 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