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Additionally, a history of depression and neuroticism have been identified as key vulnerability factors. However, the role of neuroticism remains controversial in the scientific literature, with some studies suggesting it is a stable predictor of depression, while others propose it may exhibit fluctuations in response to life events, altering its mediating role in PD. We aim to explore the role of psychological vulnerability (history of depression and neuroticism) and AD, as transdiagnostic risks factors contributing on PPD in a longitudinal sample of 229 women. Self\u2010report questionnaires were administered during pregnancy and postpartum. Results indicate that a history of depression had an indirect effect on PPD, mediated by both neuroticism and AD. Given the uncertainties regarding the stability of neuroticism, further longitudinal research is needed to clarify its mediating role in perinatal depression. These findings underscore the importance of early identification of vulnerability factors, particularly a history of depression, to prevent AD and subsequent PPD. Screening for psychological vulnerability is essential in clinical practice. Early identification of psychological vulnerability may help reduce the risk of postpartum depression. Screening for these factors during pregnancy could help identify women with high levels of neuroticism, who may benefit from brief, evidence\u2010based psychological interventions, such as mindfulness\u2010based cognitive therapy. Implementing targeted preventive strategies may enhance maternal mental health.<\/jats:p>","DOI":"10.1002\/jclp.70044","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:58:31Z","timestamp":1756997911000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychological Vulnerability to Perinatal Depression: A Longitudinal Mediation Model"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-9567","authenticated-orcid":false,"given":"Maria","family":"Provencio","sequence":"first","affiliation":[{"name":"Facultad de Psicolog\u00eda y Ciencias de la Salud Universidad a Distancia de Madrid (UDIMA) Collado Villalba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-0405","authenticated-orcid":false,"given":"Maria F.","family":"Rodr\u00edguez\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Psychology Universidad Nacional de Educaci\u00f3n a Distancia Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-8407","authenticated-orcid":false,"given":"Katina","family":"Kovacheva","sequence":"additional","affiliation":[{"name":"Universidad Miguel Hern\u00e1ndez de Elche Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-464X","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"L\u00f3pez\u2010Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Facultad HM de Ciencias de la Salud de la Universidad Camilo Jos\u00e9 Cela Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-1406","authenticated-orcid":false,"given":"Ana","family":"Fonseca","sequence":"additional","affiliation":[{"name":"University of Coimbra, Center for Research in Neuropsychology and Cognitive\u2010Behavior Interventions Faculty of Psychology and Educational Sciences Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5421-0497","authenticated-orcid":false,"given":"Cristina","family":"Soto\u2010Balbuena","sequence":"additional","affiliation":[{"name":"Servicio de Salud del Principado de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Macayo\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Servicio de Salud del Principado de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-022-02386-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00594.xCitations:74"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200109000-00004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.75.3.729"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.11.014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.05.010"},{"issue":"5","key":"e_1_2_10_8_1","first-page":"831","article-title":"[Psychometric Properties of a Scale: Internal Consistency]","volume":"10","author":"Campo\u2010Arias A.","year":"2008","journal-title":"Revista de salud publica (Bogota, Colombia)"},{"key":"e_1_2_10_9_1","volume-title":"Revised NEO Personality Inventory (NEO\u2010PI\u2010R) and NEO Five\u2010Factor Inventory (NEO\u2010FFI) professional manual","author":"Costa P. 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