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An important step to increase awareness for timely diagnosis and treatment of cluster\u2010C PDs is to investigate the burden of disease in terms of quality of life (QoL), daily functioning and the associated costs to society. In addition, a comparison between these patients and a control group can give insight into (1) the actual societal costs that are associated to cluster\u2010C PD problems and (2) potential societal savings to be made from therapeutic interventions. This study included a total of 375 treatment seeking individuals from 10 mental health sites for outpatient treatment in the Netherlands and 104 individuals without severe mental health issues from the general population. Both QoL (EQ\u20105D\u20105L and the MHQoL\u20107D) and general functioning (WHODAS) were assessed as well as a comprehensive cost\u2010interview to measure relevant costs considering a societal perspective. Results indicate that individuals with a cluster\u2010C PD have severely impaired QoL and functioning compared to the control group. The annual costs associated with cluster\u2010C PD were estimated ranging from \u20ac27,355 to \u20ac60,454 per patient per year depending on the valuation method used. These costs equate 2.8\u20134.2 times more than those of control group. Looking at the subgroup in cluster\u2010C PD, no differences in QoL, functioning or societal costs were found between individuals with avoidant, dependent and obsessive\u2010compulsive PD. Overall, the findings advocate for more financial resources to study, prevent and treat cluster\u2010C PDs.<\/jats:p>","DOI":"10.1002\/jclp.70109","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:19:52Z","timestamp":1773004792000},"page":"775-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Burden of Disease of Treatment\u2010Seeking Patients With a Cluster\u2010C Personality Disorder\u00a0in the Netherlands; Quality of Life, Functioning, and Societal Costs"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-4567","authenticated-orcid":false,"given":"Iuno Z.","family":"Groot","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology University of Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnoud","family":"Arntz","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology University of Amsterdam Amsterdam the Netherlands"},{"name":"Academic Center for Trauma and Personality (ACTP) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6002-6892","authenticated-orcid":false,"given":"Carlijn J. 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