{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:51:05Z","timestamp":1783453865577,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clin Psychol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigates the adjunctive effects of mindfulness\u2010based cognitive therapy (MBCT) combined with escitalopram hydrobromide on cognitive function and emotional well\u2010being in older adults with treatment\u2010resistant depression (TRD). We hypothesized that this combined approach would lead to greater enhancements in cognitive abilities and overall well\u2010being compared to escitalopram hydrobromide alone in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 230 older adults with TRD and cognitive impairment were randomly assigned into two groups: an experimental group receiving MBCT plus escitalopram (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009115) and a control group receiving escitalopram alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009115). Cognitive function, depression severity, and quality of life were assessed at baseline, 6 weeks, and 12 weeks using the Montreal Cognitive Assessment (MoCA), Hamilton Depression Rating Scale (HAM\u2010D), and General Quality of Life Index\u201074 (GQOLI\u201074).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The experimental group demonstrated significant improvements in cognitive function (MoCA scores) and quality of life (GQOLI\u201074 scores) compared to the control group at both 6 and 12 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additionally, depression severity (HAM\u2010D scores) was significantly reduced in the experimental group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The combined therapy also resulted in higher rates of significant and effective treatment outcomes, with fewer cases of average or ineffective responses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The integration of MBCT with escitalopram hydrobromide significantly enhances cognitive function, reduces depressive symptoms, and improves quality of life in older adults with TRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>Clinicians should consider incorporating mindfulness\u2010based interventions alongside pharmacological treatments for older adults with TRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The trial was retrospectively registered with ClinicalTrials. gov (Identifier: NCT07077291).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jclp.70137","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:36:44Z","timestamp":1776944204000},"page":"1111-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining Mindfulness\u2010Based Cognitive Therapy With Escitalopram for Cognitive and Emotional Recovery in Older Adults With Treatment\u2010Resistant Depression"],"prefix":"10.1002","volume":"82","author":[{"given":"Zhaohui","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Endocrinology Leting County Hospital Leting China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leting County TCM Hospital Leting China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Leting County Hospital Leting China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Leting County Hospital Leting China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Leting County Hospital Leting China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6705-7807","authenticated-orcid":false,"given":"Aiping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurology Leting County Hospital Leting China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.14036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12925"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.05.023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-023-03220-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.05.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S434130"},{"key":"e_1_2_9_9_1","volume-title":"Structured Clinical Interview for DSM\u20105 Disorders, Clinician Version (SCID\u20105\u2010CV)","author":"First M. 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