{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:46:48Z","timestamp":1791139608015,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The latent TGF\u2010\u03b2 binding protein (LTBP)\u20103 is an extracellular matrix (ECM) protein that binds the small latent complex (SLC) of TGF\u2010\u03b2. Disruption of the <jats:italic>Ltbp\u20103<\/jats:italic> gene by homologous recombination in mice yields mutant animals that display multiple skeletal abnormalities. In addition, these mice have retarded growth. On an inbred 129 SvEv background, half of the Ltbp\u20103 mutant mice die between 3 and 4 weeks after birth. These mice show severe involution of the thymus and spleen and a sharp reduction in the numbers of CD4\/CD8 double positive T\u2010cells in the thymus. The thymus and spleen defect is caused by elevated corticosterone levels in the serum and can be reversed by injection of aminoglutethimide (AMG), an inhibitor of steroid synthesis. This result indicates that the thymus and spleen defect is a secondary defect due to high corticosterone levels probably induced by stress of unknown etiology. J. Cell. Physiol. 196: 319\u2013325, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.10296","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T10:10:19Z","timestamp":1055412619000},"page":"319-325","source":"Crossref","is-referenced-by-count":21,"title":["Growth retardation as well as spleen and thymus involution in latent TGF\u2010\u03b2 binding protein (Ltbp)\u20103 null mice"],"prefix":"10.1002","volume":"196","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Dabovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Colarossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio R.","family":"Santori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Lilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Vukmanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Rifkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.309"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.2144\/00295st04"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02648-0"},{"key":"e_1_2_4_5_1","first-page":"363","article-title":"Glucocorticoid\u2010induced apoptosis in the thymus","volume":"4","author":"Cohen JJ","year":"1992","journal-title":"Semin Immunol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200111080"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1750129"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.2.539"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.19.4267"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.47.29891"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri704"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624797"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1978.235.5.E451"},{"key":"e_1_2_4_14_1","volume-title":"Immunobiology: The immune system in health and disease, 3rd edition","author":"Janeway CA","year":"1997"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010215)52:4<354::AID-JEMT1020>3.0.CO;2-G"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-95-5-1195"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041210123"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.137"},{"key":"e_1_2_4_19_1","first-page":"116","volume-title":"Production of targeted embryonic stem cell clones, in gene targeting, a practical approach, 2nd edition","author":"Matise MP","year":"2000"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb08049.x"},{"key":"e_1_2_4_21_1","first-page":"177","volume-title":"Chapter 5, Production and analysis of ES cell aggregation chimeras. 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