{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:39:14Z","timestamp":1762270754479},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":11084,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1974,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>cAMP, dbcAMP, cCMP, cGMP, theophylline and caffeine caused reversible melanosome dispersion within 5 minutes at 10 mM in the dermal melanophores of the black goldfish, <jats:italic>Carassius auratus<\/jats:italic> L. cTMP, cUMP, 5\u2032\u2010AMP, 5\u2032\u2010CMP, 5\u2032\u2010GMP, 5\u2032\u2010TMP, and 5\u2032\u2010UMP did not produce melanosome dispersion or aggregation in this melanophore system. cAMP was the most effective nucleotide in the induction of melanosome dispersion; at 10 mM, cGMP and at 5 mM, dbcAMP were the least effective of those nucleotides inducing melanosome dispersion. At the 10 mM level dbcAMP required 30 minutes to evoke the same degree of melanosome dispersion as 5 minutes cAMP treatment. Theophylline was more effective than caffeine in eliciting melanosome dispersion. At 1 mM, theophylline and caffeine first induced melanosome dispersion which was followed by aggregation in the course of the 30 minute test period. These reactions suggest both a high melanophore phosphodiesterase activity and competitive inhibition of phosphodiesterase by theophylline and caffeine. Induction of melanosome dispersion by several cyclic 3\u2032,5\u2032\u2010nucleotides suggest multi\u2010nucleotide control of melanosome dispersion. These findings also support a proposed mechanism of prostaglandin induced melanosome dispersion as well as the \u201csecond messenger\u201d hypothesis.<\/jats:p>","DOI":"10.1002\/jcp.1040840216","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T17:48:39Z","timestamp":1109440119000},"page":"301-309","source":"Crossref","is-referenced-by-count":16,"title":["In vitro response of goldfish (<i>Carassius auratus<\/i> L.) dermal melanophores to cyclic 3, 5\u2032\u2010nucleotides, nucleoside 5\u2032\u2010phosphates and methylxanthines"],"prefix":"10.1002","volume":"84","author":[{"given":"Joel","family":"Abramowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Chavin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/z70-097"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-84-2-362"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(73)90116-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/2081282a0"},{"key":"e_1_2_1_6_1","first-page":"83","article-title":"Activation of melanoma adenyl cyclase by MSH","volume":"54","author":"Bitensky M. 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