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Though ACTH and 8\u2010Br\u2010cAMP treated cells were larger with increased macromolecular synthetic rates compared to cells arrested in G<jats:sub>1<\/jats:sub> by serum removal, a similar 8\u2010 to 10\u2010hour lag to initiation of DNA synthesis was observed after either ACTH or 8\u2010Br\u2010cAMP removal or after serum addition. After the 8\u2010 to 10\u2010hour lag period, cells entered S phase exponentially. ACTH or 8\u2010Br\u2010cAMP opposed serum induced DNA synthesis initiation only when added prior to S. Once commitment to DNA synthesis occurred, ACTH or 8\u2010Br\u2010cAMP addition did not inhibit DNA synthesis although 8\u2010Br\u2010cAMP induced a secondary block in G<jats:sub>2<\/jats:sub>. Though ACTH and 8\u2010Br\u2010cAMP inhibited serum induced initiation of DNA synthesis and did not affect serum induced cellular hypertrophy, both substances increased the steroidogenic capacity of the cell. ACTH and 8\u2010Br\u2010cAMP thus appear to specifically oppose the stimulatory effects of serum on initiation of DNA synthesis while inducing the differentiated function of the cell.<\/jats:p>","DOI":"10.1002\/jcp.1040920109","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T17:08:11Z","timestamp":1109437691000},"page":"65-75","source":"Crossref","is-referenced-by-count":18,"title":["Hormonal regulation of initiation of DNA synthesis and of differentiated function in Y\u20101 adrenal cortical cells"],"prefix":"10.1002","volume":"92","author":[{"given":"Gordon N.","family":"Gill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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