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Phagocytosis of viable <jats:italic>Staphylococcus aureus<\/jats:italic> was unaffected by tobacco smoke. Glucose oxidation measured by conversion of glucose\u20101\u2010<jats:sup>14<\/jats:sup>C to <jats:sup>14<\/jats:sup>CO<jats:sub>2<\/jats:sub> was moderately affected while oxidation of glucose\u20106\u2010<jats:sup>14<\/jats:sup>C to <jats:sup>14<\/jats:sup>CO<jats:sub>2<\/jats:sub> was not. Smokers routinely yielded fewer cells than controls, though these cells contained approximately 17% more protein than did controls. Opsonization of particles was not necessary for macrophages from either smoker or control animals to manifest a respiratory burst and increased superoxide and hydrogen peroxide release during phagocytosis. The glycolytic inhibitors, sodium fluoride and iodoacetamide, while effectively blocking glycolysis, did not inhibit phagocytosis by macrophages from either group. The results reported clearly distinguish alveolar macrophages from other phagocytic cells (peritoneal macrophages and polymorphonuclear leukocytes) and suggest a state of non\u2010specific activation caused by exposure to tobacco smoke.<\/jats:p>","DOI":"10.1002\/jcp.1040950113","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T16:53:51Z","timestamp":1109436831000},"page":"105-113","source":"Crossref","is-referenced-by-count":28,"title":["The effect of tobacco smoke on the metabolism and function of rat alveolar macrophages"],"prefix":"10.1002","volume":"95","author":[{"given":"David B.","family":"Drath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Gharibian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred L.","family":"Karnovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107236"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0021-9258(18)70393-1","article-title":"Occurrence and control of the phosphogluconate oxidation pathway in normal and leukemic leukocytes","volume":"232","author":"Beck W. 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