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Arborization of the SMC correlated closely with increases in cellular cAMP produced by IP and a variety of other compounds. The intracellular calcium antagonist 8\u2010(N,N\u2010diethylamino)\u2010octyl\u20103,4,5\u2010trimethoxybenzoate (TMB\u20108) also rounded and arborized the SMC. Antitubulin compounds potently blocked arborization by IP, dibutyryl cAMP, and TMB\u20108. The release of cell\u2010bound <jats:sup>45<\/jats:sup>Ca<jats:sup>2+<\/jats:sup> was followed in the presence and absence of IP. IP strikingly increased the amount of <jats:sup>45<\/jats:sup>Ca<jats:sup>2+<\/jats:sup> that remained cell bound between 20 and 120 min Propranolol and colchicine prevented IP from inhibiting the release of cell\u2010bound <jats:sup>45<\/jats:sup>Ca<jats:sup>2+<\/jats:sup>. These results suggest that the modulation of Ca<jats:sup>2+<\/jats:sup> transport is involved in the arborization of cultured SMC by cAMP.<\/jats:p>","DOI":"10.1002\/jcp.1041210215","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T14:21:37Z","timestamp":1109427697000},"page":"375-382","source":"Crossref","is-referenced-by-count":21,"title":["\u03b2\u2010Adrenergic stimulation inhibits calcium efflux and alters the morphology of cultured arterial muscle cells"],"prefix":"10.1002","volume":"121","author":[{"given":"Jeffrey Bingham","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1016\/S0021-9258(18)50350-1","article-title":"The effect of ionomycin on calcium fluxes in sarcoplasmic reticulum vesicles and liposomes","volume":"254","author":"Beeler T. 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