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Direct WGA\u2010stimulation of Intestine 407 cells leads to an immediate rise in the cytosolic\u2010free calcium concentration. The major part of this lectin\u2010induced rise is due to an influx of calcium across the plasma membrane into the cytosol. However, WGA\u2010exposure also results in an immediate mobilization of calcium from intracellular stores, most likely mediated via the simultaneous increase of inositol trisphosphate formation in these cells. The transduction mechanism described for WGA in these intestinal cells is not very sensitive towards pertussin toxin, indicating that if a G\u2010protein is involved, it differs from those of most other systems. The suggested role for WGA in changing the functional and structural properties of intestinal cells might involve increases of inositol phosphate and cytosolic\u2010free calcium levels.<\/jats:p>","DOI":"10.1002\/jcp.1041340320","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T11:26:57Z","timestamp":1109417217000},"page":"473-478","source":"Crossref","is-referenced-by-count":10,"title":["Direct effects of wheat germ agglutinin on inositol phosphate formation and cytosolic\u2010free calcium level in intestine 407 cells"],"prefix":"10.1002","volume":"134","author":[{"given":"Anita","family":"Sj\u00f6lander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)80565-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2400333"},{"key":"e_1_2_1_4_1","first-page":"437","article-title":"Characterization of fMet\u2010Leu\u2010Phe receptor\u2010mediated Ca2+ influx across the plasma membrane of human neutrophils","volume":"30","author":"Andersson T.","year":"1986","journal-title":"Mol. 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