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TGF\u2010\u03b2 synergistically enhanced both the TNF\u2010 and EGF\u2010stimulated cell growth, whereas synergism between the mitogenic action of EGF and that of TNF was not observed. When indomethacin or acetylsalicylic acid, an inhibitor of prostaglandin production, was added to FS\u20104 cells, cell growth stimulated by EGF or TNF was increased, suggesting that prostaglandins induced by these mitogens antagonize their growth stimulatory actions. In contrast, neither indomethacin nor acetylsalicylic acid had a significant effect on the TGF\u2010\u03b2\u2010induced growth of FS\u20104 cells. Mitogenic responses of indomethacin\u2010treated cells to EGF, TNF, and TGF\u2010\u03b2 were similarly suppressed by the addition of exogenous prostaglandin D<jats:sub>2<\/jats:sub> (PGD<jats:sub>2<\/jats:sub>). Other prostaglandins such as PGE<jats:sub>2<\/jats:sub> and PGF<jats:sub>2\u03b1<\/jats:sub> produced less inhibition of the cell growth.<\/jats:p>","DOI":"10.1002\/jcp.1041410207","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T09:42:25Z","timestamp":1109410945000},"page":"275-280","source":"Crossref","is-referenced-by-count":35,"title":["Possible role of prostaglandins as negative regulators in growth stimulation by tumor necrosis factor and epidermal growth factor in human fibroblasts"],"prefix":"10.1002","volume":"141","author":[{"given":"Takamitsu","family":"Hori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kashiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makio","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayumi","family":"Shibamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Oku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90881-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1016\/S0021-9258(18)68575-8","article-title":"Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells: Induction of prostaglandin H2 synthase","volume":"263","author":"Casey M. 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