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Such glutamine dependency has a good inverse correlation with the activity of glutamine synthetase. Moreover, glutamine synthetase can be induced in glutamine\u2010deficient media, especially in glutamine\u2010independent cells. In HL\u201060 cells, glutamine deprivation results in the decrease of both ATP and dATP levels. The addition of adenine to the culture medium abolishes these changes without restoring cell growth, indicating that the effects of glutamine deprivation on cell growth cannot be fully explained by the perturbation of adenine nucleotide pools.<\/jats:p>","DOI":"10.1002\/jcp.1041430120","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T09:58:24Z","timestamp":1109411904000},"page":"150-153","source":"Crossref","is-referenced-by-count":28,"title":["Metabolic basis for differential glutamine requirements of human leukemia cell lines"],"prefix":"10.1002","volume":"143","author":[{"given":"Toshiyuki","family":"Kitoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Takimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Mikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041240216"},{"key":"e_1_2_1_3_1","first-page":"4077","article-title":"Influence of glutamine on the growth of human glioma and medulloblastoma","volume":"45","author":"Dranoff G.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041200218"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.3.713.713"},{"key":"e_1_2_1_6_1","first-page":"7348","article-title":"Regulation of de novo purine biosynthesis in human lymphoblasts","volume":"251","author":"Hershfield M. 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