{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:32:52Z","timestamp":1762144372994},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the effect of histamine generated by murine bone marrow cells in response to IL\u20103 on one particular biological activity of this growth factor, i.e., triggering of cells forming colonies in spleen (CFU\u2010S) into S phase. Evidence is provided that i) IL\u20103\u2010induced day\u20108 CFU\u2010S cell cycling, evaluated by hydroxyurea suicide, is completely abrogated when the binding of histamine to its H<jats:sub>2<\/jats:sub> receptors is blocked by the specific antagonist oxmetidine, whereas cetirizine, a H<jats:sub>1<\/jats:sub> receptor antagonist, is ineffective; and ii) the entry of day\u20108 CFU\u2010S intoS phase in response to IL\u20103 is likevise abolished when the histamine synthesis promoted by the growth factor is prevented by \u03b1\u2010fluoromethylhistidine, a specific inhibitor of the histamine\u2010forming enzyme, histidine decarboxylase. Similar results are obtained with both drugs, when a progenitor\u2010enriched bone marrow population is used instead of total cells. Furthermore, i.v. injection of recombinant (r)IL\u20103 results within 2 hr in a substantial increase in bone marrow cell histamine synthesis together with triggering of day\u20108 CFU\u2010S into cycle, the latter being completely abolished by a simultaneous injection of the H<jats:sub>2<\/jats:sub> histamine receptor antagonist oxmetidine. Thus, our findings support the notion that both in vitro and in vivo the proliferation of early CFU\u2010S in response to IL\u20103 is modulated by histamine via its H<jats:sub>2<\/jats:sub> receptors. This conclusion is also consistent with the observation that dimaprit, a specific agonist of these receptors not only enhances the sensitivity of day\u20108 CFU\u2010S to HU after a 2 hr incubation with bone marrow cells but also increases, to the same extent as IL\u20103, the number of colonies formed in irradiated spleens after a 5 hr pretreatment.<\/jats:p>","DOI":"10.1002\/jcp.1041430218","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T10:08:16Z","timestamp":1109412496000},"page":"337-343","source":"Crossref","is-referenced-by-count":40,"title":["New role for histamine in interleukin\u20103\u2010induced proliferation of hematopoietic stem cells"],"prefix":"10.1002","volume":"143","author":[{"given":"Elke","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Piquet\u2010Pellorce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Dy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07583.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood.V26.3.296.296","article-title":"The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony\u2010forming cells in mice","volume":"26","author":"Becker A. 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