{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:41:54Z","timestamp":1698068514929},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5362,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Slow Ca\u2010dependent action potentials were studied in skeletal muscle fibers from different Neuromuscular Diseases (NMD). Byopsies were obtained from: 3 <jats:italic>my<\/jats:italic>\u2010<jats:italic>opathies<\/jats:italic> [Fascioscapulohumeral Dystrophy (FSH) and Polymyositis (PM)], 6 patients with other diseases (CD) [Amyotrophic Lateral Sclerosis (ALS), Central Core Disease, Mitochondrial Myopathy, Polyneuritis (PN), von Eulenberg's Paramyotonia], and 8 <jats:italic>normal<\/jats:italic> control muscles. Experiments were carried out in muscle fibers under current\u2010clamp conditions. Membrane currents other than Ca ones were abolished or greatly diminished. Muscle fibers produced any of 3 types of responses, when stimulated by depolarizing pulses: fully developed Ca\u2010action potentials (CaAP), abortive non\u2010regenerative Ca responses (NrR), or only capacitive passive responses (WR). The 3 types of responses were not dependent on the basal conditions of the fibers. The frequency of observation of CaAPs was significantly higher in myopathic disease. In <jats:italic>myopathies<\/jats:italic>, 46% of the muscle fibers had CaAPs, while only 22% of fibers from CD and 15% of the fibers from <jats:italic>normal<\/jats:italic> muscles showed CaAPs. No differences were observed in the resting constants as well as in the CaAPs parameters between <jats:italic>normal<\/jats:italic> and diseased muscle fibers.<\/jats:p>","DOI":"10.1002\/jcp.1041430325","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T08:54:31Z","timestamp":1109408071000},"page":"590-595","source":"Crossref","is-referenced-by-count":0,"title":["Ca\u2010dependent slow action potentials in neuromuscular diseases"],"prefix":"10.1002","volume":"143","author":[{"given":"L. Nicola","family":"Siri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Dubrovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. D.","family":"Uchitel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1976.0070"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.11.1436"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.5.439"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.7.670"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/102.1.147"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014516"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160612"},{"key":"e_1_2_1_9_1","first-page":"1185","volume-title":"Myology","author":"Engel A. 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Cell. Physiol."},{"key":"e_1_2_1_21_1","first-page":"131","volume-title":"Calcium and Necrosis in Neuromuscular Diseases","author":"Sewry C. 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