{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:07:46Z","timestamp":1698037666284},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5332,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Butylated hydroxytoluene (BHT), which has both antioxidant and membrane active properties, has been reported to affect cellular differentiation. We studied its effect on the bipotent lineage differentiation of the important HL\u201060 human my\u2010eloblastic leukemia cell line using reduction of nitroblue tetrazolium, cell cycle analysis, population growth rote, monoclonal antibodies, and morphology. BHT markedly accelerated retinoic acid\u2010induced myelocytic differentiation and dihydroxyvitamin D<jats:sup>3<\/jats:sup>\u2010induced monocvtic differentiation in a concentration and time\u2010dependent manner. Butylated hydroxyanisole (BHA) had a comparable effect. Preincubation with the compounds was not necessary to evoke the acceleration. Other antioxidants and inhibitors of eicosanoid synthesis were inactive. We conclude that the important food preservatives BHT and BHA accelerate the kinetics of terminal differentiation of human leukemia and that this effect is likely due at least in part to their membrane active properties.<\/jats:p>","DOI":"10.1002\/jcp.1041440106","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T09:00:46Z","timestamp":1109408446000},"page":"36-41","source":"Crossref","is-referenced-by-count":3,"title":["Effect of butylated hydroxytoluene on biliineage differentiation of the human HL\u201060 myeioblastic leukemia cell"],"prefix":"10.1002","volume":"144","author":[{"given":"C. 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