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In an attempt to define the normal cellular targets for LIF, the distribution of LIF receptors within hemopoietic and hepatic tissue was analyzed by binding cells with radioiodinated LIF (<jats:sup>125<\/jats:sup>I\u2010LIF) and subsequently carrying out autoradiography. Autoradiography demonstrated that in each he\u2010mopoietic tissue examined cells of monocyte\/macrophage lineage were the primary cell type labeled with <jats:sup>125<\/jats:sup>I\u2010LIF. Moreover, both fetal and adult parenchy\u2010mal hepatocytes displayed higher levels of labeling than either monocytes or macrophages. The number of receptors per positive cell varied from 150 for bone marrow monocytes to 2,000 for adult hepatocytes. In each case, however, binding was of high affinity, with an apparent K<jats:sub>D<\/jats:sub> of 34\u2013100 pM, and binding was specific, since labeling was competed for by unlabeled LIF but not a range of other structurally unrelated growth and differentiation factors. It is suggested that LIF may play a role in regulating macrophage function and hepatic acute phase protein synthesis in response to infection.<\/jats:p>","DOI":"10.1002\/jcp.1041460204","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T08:41:29Z","timestamp":1109407289000},"page":"207-215","source":"Crossref","is-referenced-by-count":93,"title":["Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells"],"prefix":"10.1002","volume":"146","author":[{"given":"Douglas J.","family":"Hilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicos A.","family":"Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Metcalf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.16.5958"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.91.3.848"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2120259"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14383.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(83)92025-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7251"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02742.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.8.2623"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90200-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1016\/S0021-9258(19)76530-2","article-title":"Resolution and purification of three distinct factors produced by Krebs ascites cells which have diffentiation\u2010inducing activity for murine myeloid leukemic cell lines","volume":"263","author":"Hilton D. 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