{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T10:33:25Z","timestamp":1782038005236,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5028,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Progressive stenosis or occlusion of bi ateral internal carotid arteries by fibrocellular intimal thickening results in cerebral ischemia in moyamoya disease. The etiology is unknown. We examined cultured arterial smooth muscle cells (SMC) from scalp arteries of five patients with moyamoya disease. In this study we investigated the responsiveness of the cells in culture to serum mitogens including platelet\u2010derived growth factor (PDGF), a major mitogen of SMC, and compared the response to that of cells derived from age\u2010matched control patients. SMC from patients with moyamoya disease proliferated less rapidly in a medium with 15% serum than did control SMC and responded poorly to the addition of PDGF to 5% serum. PDGF alone did not stimulate SMC in a quiescent state to initiate DNA synthesis in moyamoya disease, without serum factors other than bovine serum albumin, though it significantly stimulated the controls. Simultaneous additions of epidermal growth factor, insulin\u2010like growth factor\u2010I, and PDGF stimulated initiation of DNA synthesis in cells from moyamoya disease, but not as much as PDGF alone did in the controls. Although direct correlations with the pathogenesis of the disease remain to be clarified, the results indicate altered interrelations between serum factors and the cellular responses in vessels of moyamoya disease.<\/jats:p>","DOI":"10.1002\/jcp.1041470202","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T08:42:47Z","timestamp":1109407367000},"page":"191-198","source":"Crossref","is-referenced-by-count":57,"title":["Altered cellular responses to serum mitogens, including platelet\u2010derived growth factor, in cultured smooth muscle cells derived from arteries of patients with moyamoya disease"],"prefix":"10.1002","volume":"147","author":[{"given":"Masaru","family":"Aoyagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Fukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Shinkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6844921"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34650-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1979.59.1.1","article-title":"The smooth muscle cell in culture","volume":"53","author":"Chamley\u2010Campbell J.","year":"1979","journal-title":"Physiol. Rev."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041400108"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.3.418"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111906"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.1919"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/295419a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510070101025"},{"key":"e_1_2_1_11_1","unstructured":"Fukai N. Aoyagi M. Yamamoto M. Sakamoto H. Shinkai T. Matsushima Y. andYamamoto K. Establishment and characterization of human diploid arterial smooth muscle cells HMSMC from patients with moyamoya disease. Submitted."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/311433a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/1.4.348"},{"key":"e_1_2_1_14_1","first-page":"11","article-title":"Spontaneousocclusion of the circle of Willis","volume":"1","author":"Haltia M.","year":"1982","journal-title":"Clin. Neuropathol."},{"key":"e_1_2_1_15_1","first-page":"328","article-title":"The spontaneous occlusion of the circle of Willis ((Moyamoya) disease)","volume":"32","author":"Handa H.","year":"1988","journal-title":"Shinkeishimpo"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(65)90211-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.1.307"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3664"},{"key":"e_1_2_1_19_1","first-page":"221","article-title":"Pathology of so\u2010called \u201cspontaneous occlusion of the circle of Willis.\u201d","volume":"19","author":"Hosoda Y.","year":"1984","journal-title":"Pathol. Annu."},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"8130","DOI":"10.1016\/S0021-9258(18)34306-0","article-title":"Platelet\u2010derived growth factor. Specific binding to target cells","volume":"257","author":"Huang J. S.","year":"1982","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1973.tb01303.x"},{"key":"e_1_2_1_22_1","first-page":"119","article-title":"Moyamoya disease in twins","volume":"39","author":"Kawamura S.","year":"1987","journal-title":"Brain Nerve (Tokyo)"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90092-2"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.3.208"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.11.1048"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.5.485"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.3.623"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806093182303"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(83)90285-9"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2829356"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(81)80017-1"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80668-9"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(83)90001-0"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.13.4418"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1968.29.3.0255"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(80)90083-2"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.6.2839"},{"key":"e_1_2_1_38_1","first-page":"513","article-title":"A reassessment of endothelial injury and arterial lesion formation","volume":"53","author":"Reidy M. A.","year":"1985","journal-title":"Lab. Invest."},{"key":"e_1_2_1_39_1","first-page":"382","article-title":"Familial moyamoya associated with biochemical abnormalities of connective tissue","volume":"27","author":"Richman D. P.","year":"1977","journal-title":"Neurology"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.4.1207"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608122950707"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608192950805"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92760-8"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/311669a0"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90033-9"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.12.1149"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0309-1651(88)90154-3"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1279"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.1.104"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.4.728"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7311"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1980.53.1.0109"},{"key":"e_1_2_1_54_1","first-page":"213","article-title":"Immunocytochemical identification of \u03b2\u2010protein precursor in cultured vascular cells","volume":"17","author":"Yamamoto K.","year":"1990","journal-title":"Artery"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.1.50"},{"key":"e_1_2_1_56_1","first-page":"9","article-title":"Comparative studies on the sensitivity of three methods for detecting mycoplasmal contamination in cell cultures","volume":"4","author":"Yoshida T.","year":"1988","journal-title":"Bull. J. F. C. C."}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.1041470202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.1041470202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:45:13Z","timestamp":1698047113000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.1041470202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,5]]}},"alternative-id":["10.1002\/jcp.1041470202"],"URL":"https:\/\/doi.org\/10.1002\/jcp.1041470202","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5]]}}}