{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:27:38Z","timestamp":1779150458529,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4783,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C57BL\/6(B6)\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> mice are sterile due to the defective spermatogenesis in the testes. To know the cause of the deficient spermatogenesis in B6\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> mice, we examined whether the problem is within or outside the seminiferous tubules by transplanting tubules from cryptorchid testes of B6\u2212+\/+ mice into B6\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> testes or tubules from B6\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> mice into testes of (WB \u00d7 C57BL\/6)F1\u2010<jats:italic>W<\/jats:italic>\/<jats:italic>W<\/jats:italic> (hereafter, WBB6F1\u2010<jats:italic>W<\/jats:italic>\/<jats:italic>W<\/jats:italic>) mice. Type A spermatogonia differentiated into spermatids in seminiferous tubules from cryptorchid testes transplanted into B6\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> testes. In contrast, in B6\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> tubules transplanted into WBB6F1\u2010<jats:italic>W<\/jats:italic>\/<jats:italic>W<\/jats:italic> testes, type A spermatogonia were stimulated to mitotic proliferation, but didn't proceed to any differentiated germ cells. The present results suggest that the cause of the deficient spermatogenesis in B6\u2010<jats:italic>jsd<\/jats:italic>\/<jats:italic>jsd<\/jats:italic> mice is a defect of intratubular environment to support germ cell differentiation.<\/jats:p>","DOI":"10.1002\/jcp.1041500125","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T07:21:00Z","timestamp":1109402460000},"page":"188-193","source":"Crossref","is-referenced-by-count":27,"title":["Loss of sperm in juvenile spermatogonial depletion (<i>jsd<\/i>) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation"],"prefix":"10.1002","volume":"150","author":[{"given":"Masumi","family":"Mizunuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Dohmae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichi","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uichi","family":"Koshimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitake","family":"Nishimune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0560099"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10799898409041862"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod38.4.899"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0850771"},{"key":"e_1_2_1_6_1","first-page":"281","volume-title":"The Molecular and Cellular Endocrinology of Testis","author":"Fauser B. 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