{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:51:06Z","timestamp":1790373066083,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4509,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transforming growth factor\u2010beta 1 (TGF\u2010\u03b21) has been implicated in a variety of responses associated with wound healing and inflammation. Thus, TGF\u2010\u03b21 enhances production of several extracellular matrix proteins both in vitro and in vivo, is chemotactic for monocytes, and alters the functioning of lymphocytes. We have examined the ability of TGF\u2010\u03b21 to affect the behavior of human THP\u20101 promonocytic leukemia cells, a cell line with the capacity to differentiate into macrophage\u2010like cells. TGF\u2010\u03b21 reduces the growth rate of these cells, induces morphologic changes, and promotes adherence to culture surfaces. In addition, the adherent cell population expresses high levels of esterase activity, acquires the ability to ingest latex beads, and releases elevated levels of interleukin 1. TGF\u2010\u03b21\u2010treated cells also express elevated levels of the \u03b2<jats:sub>2<\/jats:sub> family of integrins. Taken together, these results suggest that TGF\u2010\u03b21 is capable of promoting the maturation of promonocytic cells into macrophages. This outcome has implications at wound sites where TGF\u2010\u03b21 and a myriad of other factors interact with many cell types to facilitate healing. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.1041530106","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T07:01:26Z","timestamp":1109401286000},"page":"30-37","source":"Crossref","is-referenced-by-count":32,"title":["TGF\u2010beta inhibits proliferation of and promotes differentiation of human promonocytic leukemia cells"],"prefix":"10.1002","volume":"153","author":[{"given":"Christine","family":"Bombara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Ignotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69173-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90448-N"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.142.12.4295"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02449.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0021-9258(17)31269-3","article-title":"Regulation of cell adhesion receptors by transforming growth factor\u2010\u03b2: Concomitant regulation of integrins that share a common \u03b21 subunit","volume":"264","author":"Heino J.","year":"1989","journal-title":"J. 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